壳聚糖-三七总皂苷缓释微囊的制备及体外溶出研究  

Preparation and in vitro Release of CTS-PNS Sustained Release Microcapsules

作　　者：王家远[1] 杨波[1] 赵榆林[1] 杨明慧[2] 王晓科[1] 

机构地区：[1]昆明理工大学生化学院化工系,云南昆明650224 [2]大理学院生化系,云南大理671000

出　　处：《中国药业》2006年第17期28-29,共2页China Pharmaceuticals

基　　金：云南省教育厅科学基金项目;项目编号:04Y461D;02ZY169。

摘　　要：目的探讨制备壳聚糖(CTS)-三七总皂苷(PNS)缓释微囊的工艺条件,确定微囊的缓释作用。方法以壳聚糖为载体,采用乳化化学交联技术,制备壳聚糖-三七总皂苷微囊,并考察微囊的基本特性及其体外溶出性能。结果微囊的最优工艺条件为3%壳聚糖溶液,壳聚糖/三七总皂苷为2：1,在60℃下交联2h。结论体外释放度试验表明,药物释放速度较缓慢,缓释效果明显。Objective To study the preparation condition of CTS- PNS sustained release microcapsules, and to confirm the effect of sustained release. Methods Crossing- linked CTS microcapsules containing PNS were achieved by emulsification and cross- linking technology. The properties and performances in vitro release of the microcapsules were investigated. Results Experimental design was applied to optimize the preparation procedure of the microcapsules： 3% CTS concentration,CTS/PNS 2 ： 1, crossing-linked 2 h under 60℃. The drug release characteristics of the microcapsules were studied. Conclusion The microcapsules have better effect of sustained release.

关 键 词：三七总皂苷 壳聚糖 微囊 缓释 

分 类 号：TQ460.72[医药卫生—药物分析学]