P2Y12基因多态性与冠心病的相关性研究  

Study on correlation of P2Y12 gene polymorphisms with coronary atherosclerotic heart disease

作　　者：耿嘉正[1] 刘传新[2] 关晶[2] 张思仲[1] 

机构地区：[1]四川大学华西医院 [2]济宁医学院

出　　处：《山东医药》2006年第29期12-14,共3页Shandong Medical Journal

基　　金：国家科技攻关计划子课题项目(2002BA711A08)

摘　　要：目的探讨P 2Y 12基因多态性与冠心病(CHD)的相关性。方法177例CHD患者为观察组,61例健康成年人为对照组。应用PCR-RFLP技术检测两组P 2Y 12基因C 34T、G 52T突变基因型。结果观察组C 34T多态位点T突变等位基因频率显著高于对照组,ACS与SAP间比较无统计学意义。T等位基因与CHD正关联。G 52T多态等位基因频率和基因型频率在两组间分布差异均无统计学意义。结论CHD患者存在P 2Y 12基因多态性;T突变型等位基因可能具有提高个体对CHD的易感性及个体凝血系统活化水平的作用。[Objective] To examine the distribution of P2Y12 gene polymorphisms in Chinese population and the correlatio of these polymorphisms with atherosclerotic heart disease （CHD）. [Methods] Genotypes and frequencies of two sites were examined by polymerase chain reaction -restriction fragment length polymorphism technique in 61 unrelated normal control individuals and 177 CHD patients. [Results] The frequency of T allele in CHD patients was significantly higher than that in controls. When the patients were divided into acute coronary syndrome （ACS）and stable angina pectoris（SAP）, the frequency of T allele in ACS patients was higher than that in controls, there was no significant difference between ASC patients and SAP patients. While the frequency of T allele in SAP patients was higher than that in controls. There was a positive correlation between T allele and CHD. The distributions of G52T allelic and genotype frequencies did not significantly differ between CHD patients and controls. [Conclusion] T allele for site 34 of P2Y12 gene may has the positive effect on the susceptibility of CHD and high level of coagulation response.

关 键 词：P2Y12基因 单核苷酸多态 疾病基因组 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]