乳晕入路腔镜甲状腺手术对机体免疫功能影响的研究  

Clinical trial of the effect of endoscopic thyroidectomy via breast areola approach on systemic immunity

作　　者：吴东波[1] 王存川[2] 胡友主[2] 陈均金[2] 

机构地区：[1]广西壮族自治区人民医院小儿外科,广西南宁530021 [2]暨南大学附属第一医院微创外科中心,广东广州510630

出　　处：《中国内镜杂志》2006年第9期930-932,共3页China Journal of Endoscopy

摘　　要：目的研究乳晕入路腔镜甲状腺手术对机体免疫功能的影响。方法选择20例乳晕入路腔镜甲状腺切除术病人作为试验组,另26例传统甲状腺切除术病人作为对照组。受试者分别于术前24h、术后24h和术后72h采血,送检CD3、CD4+、CD4+/CD8+I、gGI、gMI、gA、C3和C4。结果在试验组中,CD3细胞和CD4+细胞的百分比、CD4+/CD8+比值和C3在术后24h均较术前明显下降(P<0.01～0.05),IgG在术后72h亦较术前下降(P<0.05);试验组各免疫指标手术前后的变化与对照组相比差别均无统计学意义(P>0.05)。结论尽管ETBAA术后机体的免疫功能受到一定程度的抑制作用,但与传统甲状腺切除术相比并无明显差别。[Objective] To study the effect of endoscopic thyroidectomy via breast areola approach （ETBAA）on systemic immunity. [Methods] 20 patients undergoing ETBAA were allocated to a endoscopic thyroidectomy group, and another 26 patients undergoing traditional thyroidectomy were allocated to a control group. Venous blood was taken from all the patients at 24h pre-operatively and at 24 h and 72 h post-operatively for analysis of CD3, CD4^＋, CD4^＋/CD8^＋, IgG, IgM, IgA, C3, and C4. [Results] （1） In endoscopic thyroidectomy group, the percentage of CD3 and CD4^＋, the ratio of CD4^＋/CD8^＋, and C3 decreased significantly at 24 h after surgery （P 〈0.01～0.05）. IgG decreased significantly at 72 h after surgery （P 〈0.05）. （2） There was no significant difference between endoscopic thyroideetomy group and eontrol group for eaeh of the immune parameters studied. [Conclusions] ETBAA seems to be assoeiated with trauma-related immune depression, but there was no signifieant difference between ETBAA and traditional thyroideetomy on the postoperative immune depression.

关 键 词：腔镜甲状腺切除术 乳晕入路 免疫功能 

分 类 号：R581.9[医药卫生—内分泌]