重型肝炎患者血清细胞因子的变化及其临床意义  

Change and clinical significance of serum cytokin in severe hepatitis patients

作　　者：符政远[1] 李勇忠[1] 邓英[1] 蒋建勇[1] 彭吉军[1] 胡文祥[1] 李淮[1] 马孝政[1] 谢知兵[1] 

机构地区：[1]怀化市第一人民医院,湖南怀化418000

出　　处：《中国感染控制杂志》2006年第4期306-308,共3页Chinese Journal of Infection Control

摘　　要：目的 检测各期重型肝炎患者血清细胞因子的水平，探讨细胞因子在重型肝炎发病中的作用机制及临床意义。方法 设重型肝炎组和正常对照组，用酶联免疫吸附试验（ELISA）法测定每组患者血清中自细胞介素（IL）-2，IL-6，转化生长因子（TGF）β1，肿瘤坏死因子（TNF）-α，可溶性细胞凋亡因子（sFas），α-干扰素（IFN-α）的水平。结果 各期重型肝炎患者血清细胞因子的水平与正常对照组之间差异均有显著性（P〈0．05～0．001）。病情越重，IL-6，TGFβ1，TNF-α，sFas水平越高，而IL-2，IFN-α水平越低。结论 血清IL-2，IL-6，TGβ1，TNF-α，sFas，IFN-α的水平与肝细胞凋亡和坏死、损伤和修复以及病毒的复制之间存在内在联系，对评估重型肝炎的病情及预后有重要临床意义。Objective To detect serum cytokin level of severe hepatitis patients, and investigate the mechanism and clinical significance of cytokin in severe hepatitis patients. Methods There were severe hepatitis group and control group, serum level of IL-2, IL-6, TGFβ1, TNF-α, sFas and IFN-α of each group were detected with ELISA method. Results There were significant difference in serum cytokin level between severe hepatitis patients and normal control （ P〈0. 05～0. 001）, the more serious of the patients＇ conditions were, the higher level of IL-6, TGFβ1 TNF-α, sFas were, and the lower level of IL-2, IFN-α were Conclusion There are inherent relationship between the level of IL-2, IL-6, TGFβ1, TNF-α, sFas, IFN-α and hepatocellular apoptosis, necrosis, impairment, recovery and replication of virus, which has important clinical significance in evaluating patients＇ condition and prognosis of severe hepatitis.

关 键 词：重型肝炎 细胞因子 白细胞介素 肿瘤坏死因子-α Α-干扰素 转化生长因子Β1 可溶性细胞凋亡因子 

分 类 号：R512.6[医药卫生—内科学]