浙江汉族人冠心病患者载脂蛋白B基因的多态性研究  

POLYMORPHISMSOFTHEAPOLIPOPROTEINBGENELOCUSINRELATIONTOCORONARYARTERYDISEASEINZHEJIANGHANNATIONALITY

作　　者：黄元伟[1] 但青宏[1] 彭章平[1] 刘忠[1] 韩阳[1] 

机构地区：[1]浙江医科大学附属第一医院心血管研究室

出　　处：《中华医学遗传学杂志》1996年第6期341-344,共4页Chinese Journal of Medical Genetics

摘　　要：对１０３例浙江汉族人载脂蛋白（Ａｐｏ）Ｂ基因ＸｂａⅠ酶切位点，应用限制性片段长度多态性（ＲＦＬＰｓ）研究表明：（１）冠心病组中少见Ｘ２等位基因的相对频率为０．１１，显著高于正常对照组的０．０２（Ｐ＜０．０１）；（２）Ｘ２等位基因的相对频率与冠心病的病变范围无明显关联；（３）冠心病组中具Ｘ１Ｘ２基因型者与具Ｘ１Ｘ１基因型者比较，ＨＤＬ－Ｃ及ＳＯＤ水平明显降低（Ｐ分别＜０．０１，＜０．０５）。本研究结果表明，ＡｐｏＢ基因ＸｂａⅠ酶切点的ＲＦＬＰｓ可能与冠心病的发病有一定关系。XbaIrestrictionfragmentlengthpolymorphisms(RFLPs)oftheapolipoproteinB(ApoB)genewasexaminedin43unrelatedChinesepatientswithdocumentedcoronaryarterydisease(CAD)and60unrelatedhealthyChinesesubjects,usinggenomichybridizationanalysiswitha5.0kbApoBcDNAprobe.Alelefrequencieswerecomparedbetweenpatientsandcontrols,andtheirimpactonlipidandoxygenfreeradicalsmetabolismwerealsostudied.TherarealeleoftheXbaIpolymor-phism,theX2alele,wasmorefrequentinCADpatientscomparedwithcontrols(0.11vs0.02,P<0.01).CADpatientswiththegenotypeX1X2hadlowerlevelsofHDL-CandSODcomparedtothosewiththegenotypeX1X1(P<0.01,P<0.05,respectively).ThesedatasuggestthatgeneticvariationatXbaIsiteofApoBgenemaycontributetothedevelopmentofCADinChineseindividuals.

关 键 词：载脂蛋白 B基因 多态性 冠心病 

分 类 号：R541.402[医药卫生—心血管疾病]