高血压家系中高血压与血糖、血脂、体质指数和腰围关系的研究  

The Relationship between the Hypertension and the Blood Glucose,Blood Lipids,BMI and Waist Circumference in Hypertensive Pedigrees

作　　者：郝超[1] 曹杰 姜维平[1] 王亚龙[1] 张建陶[1] 张叶香[1] 顾东风 

机构地区：[1]江苏省常州市疾病预防控制中心,江苏常州213003 [2]中国医学科学院阜外医院心血管病研究所,北京100037

出　　处：《中国慢性病预防与控制》2006年第5期314-316,共3页Chinese Journal of Prevention and Control of Chronic Diseases

基　　金：常州市科研课题基金资助项目(2002-15)

摘　　要：目的探讨在高血压家系中聚集的高血压危险因素。方法2003—2004年,在江苏常州地区5个社区中,收集高血压家系104个,含直系血亲523人,其中男性278人,女性245人;旁系(配偶)265人,其中男性81人,女性184人。检测其空腹血糖(FPG)、血脂、尿酸(UA)、体质指数(BM I)及腰围,应用SPSS 11.5软件包进行统计分析。结果调整年龄、性别后,3组间两两比较发现,直系高血压组UA、FPG、甘油三酯(TG)、BM I和腰围均高于直系正常血压组,高密度脂蛋白胆固醇(H DL-C)低于直系正常血压组,差别均有统计学意义(P<0.01);直系高血压组UA、FPG、TG、TC、BM I和腰围均高于旁系正常血压组,H DL-C低于旁系正常血压组,差别均有统计学意义(P<0.01);直系正常血压组TC、腰围高于旁系正常血压组,UA低于旁系正常血压组,差别有统计学意义(P<0.05)。Logistic回归分析显示,在家族直系成员中,高血压发病与文化程度、吸烟、性格、BM I和FPG有关。结论在高血压家系中,其高血压病危险因素存在着一定的家族聚集现象。Objective To explore the risk factors in hypertension pedigrees. Methods The data of total 104 hypertension pedigrees were collected from 5 communities in Changzhou City, Jiangsu Province from 2003 to 2004. There were 523 person who were direct relatives, including 278 male, 245 female. Another 265 collateral relatives were also investigated as study objects, which included 81 male and 184 female. The serum glucose, lipid, UA level in blood, the Body Mass Index （BMI） and waistline were measured in hypertension pedigrees. The data were analyzed using Spss 11.5. Results Among direct relatives, UA, FPG, TG, BMI levels and waistline were significantly higher while HDL-C level was significantly lower in hypertension group than those in normal blood pressure group （P〈0.01）; UA, FPG, TG, BMI levels and waistline were significantly higher while HDL-C level was significantly lower in direct relative hypertension group than those in collateral relative normal blood pressure group （P〈0.01）; TC level and waistline in direct relative normal blood pressure group were significantly higher while UA level was lower than those in collateral relative normal blood pressure group （P〈0.05）. The above comparisons were all adjusted by ages and sex. Through Logistic regression analysis, the results showed that the incidence rate of hypertension in direct relatives was related with education, smoke, character, BMI and FPG. Conclusion In hypertension pedigrees, as far as risk factors for hypertension were concerned, there existed family gathering phenomenon in a certain extent.

关 键 词：高血压 家系 危险因素 

分 类 号：R541.3[医药卫生—心血管疾病]