3－酮－地索高诺酮的生物活性研究  

STUDY ON THE BIOLOGICAL ACTIVITIES OF 3-KETO-DESOGESTREL

作　　者：蒋国庆[1] 郑淑蓉[1] 严仁英[1] 

机构地区：[1]北京医科大学第一医院妇产科

出　　处：《北京医科大学学报》1996年第6期460-463,共4页Journal of Peking University(Health Sciences)

摘　　要：目的：测定３－酮－地索高诺酮在小鼠、大鼠和家兔体内的生物活性。方法：采用六点法或四点法生物检定。结果：３－酮－地索高诺酮具有很强的抗排卵活性，很高的孕激素活性，无明显的雌激素活性，有较强的抗雌激素活性，雄激素活性和同化激素活性很低。该药的生物活性选择系数明显高于左旋－１８－甲基炔诺酮，该药的生物活性选择性更专一，即保证很高孕激素活性的同时，雄激素活性进一步下降。结论：３－酮－地索高诺酮的临床应用在保证高效避孕作用的同时，可减少与雄激素活性有关的副作用。Objective:To determine the biological activities of 3-keto-desogestrel(KDG)in mouse,rats and rabbits. Methods:Four or six-point bioassay. Results:KDG was a contraceptive with strong an-tiovulation activity,very high progestogen activity,no estrogenic activity,high anti-estrogenic activity,and very low androgenic and anabolic activity.Selectivity index for biological activity of KDG was re-markably higher than that of levonorgestrel.Conclusion:KDG may be a more selective progestogen contraceptive and may produce less androgenic side-effects in clinical application.

关 键 词：地索高诺酮 避孕药 药理学 

分 类 号：R979.21[医药卫生—药品]