黄芪总苷对实验性急性胰腺炎的保护作用  

Effects of Astragalosides on Experimental Acute Pancreatitis

作　　者：孙海燕[1] 黄民[2] 关溯[2] 

机构地区：[1]深圳职业技术学院,广东深圳518055 [2]中山大学药学院,广东广州510080

出　　处：《时珍国医国药》2006年第10期1980-1981,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的 探索黄芪总苷（AST）对实验性急性胰腺炎的保护作用及其作用机理。方法 用扭体法和热板法研究其镇痛作用；用脱氧胆酸钠逆行胆胰管注射诱导急性胰腺炎模型，测定血清淀粉酶（AMS）和脂肪酶（LPS）的活性。结果 AST（20—80mg·kg^-1）均可不同程度地减轻拟痛反应，降低模型动物的血清AMS和LPS水平。结论 AST有镇痛作用和对急性胰腺炎的保护作用。Objective To study the protective effects of astragalosides （AST） on acute pancreatitis （AP） in rats. Methods AP models were induced by retrograde injection of sodium deoxycholate into bilipancreatic duct in rats. Rats were injected subcutaneously with saline, astragalosides（20,dO, 80 mg ·kg^-1 ） and octreotide（0.01 mg · kg^-1） respectively before operation. The activity of the amylase（AMS） and lipase（LPS） were measured at 6 and 12 h after induction of AP. Pathomorphology of the pancreaces was observed under the microscope. Analgesic action of AST also be observed in two kinds of models. Results It was shown that the activity of AMS and LPS in AST treated groups were much lower than that in model groups. Pathologic study showed that pancreatic leision was alleviated. The analgesic action of AST has also been proved. Conclusion AST has certain protective effects on AP.

关 键 词：黄芪总苷 镇痛 急性胰腺炎 脱氧胆酸钠 

分 类 号：R285.5[医药卫生—中药学]