聚磷酸钙多孔材料在模拟体液中的降解规律初探  

The Discussion About the Degradation of Calcium Polyphosphate in the Simulated Body Fluid

作　　者：侯旭[1] 陈元维[1] 秦滢杰[1] 唐昌伟[1] 万昌秀[1] 

机构地区：[1]四川大学医用高分子及人工器官系,成都610065

出　　处：《北京生物医学工程》2006年第5期538-541,共4页Beijing Biomedical Engineering

基　　金：国家自然科学基金(50472091);四川大学创新人才培养计划"星火"基金资助

摘　　要：从组织工程材料学角度研究和开发可控生物降解材料是生物材料科学和工程的主要任务之一。通过体外模拟实验,揭示影响材料降解的各种因素,对实现材料可控降解将具有重大意义。本文对不同晶型的聚磷酸钙多孔支架材料,对比其在模拟体液和三羟甲基氨基甲烷缓冲液中的降解规律,结果表明体液中无机成分对聚磷酸钙支架材料的降解特性有明显影响,在模拟体液中进行聚磷酸钙的模拟降解更接近体内环境,因而更有利于揭示聚磷酸钙的体内降解规律,此结果为实现聚磷酸钙的可控降解提供有用的参考。According to material of tissue engineering, the research and exploiture of the controllable material of biedegradation is one of the main missions of biomaterials＇ science and engineering. Base on simulated experiment in vitro, various factors about the degradation of material are opened out. So it has the great significance towards carrying out the controllable material of biedegradation. This paper bases on the degradation of Porous CPP scaffolds with different crystal structures in Tris-buffered solution and simulated body fluid （SBF） was carried out. Results indicated that the CPP scaffolds in SBF was better than those in Tris-buffered solution as buffered solution to reveal the rule of degradation in vivo. And it also provides the useful reference for the realization of controllable degradation of CPP.

关 键 词：聚磷酸钙 模拟体液 体外降解 

分 类 号：R318.08[医药卫生—生物医学工程]