老年慢性阻塞性肺病患者静脉血和唾液茶碱浓度相关性研究  

Study on Correlation Among Theophylline Concentrations of Venous Blood and Salivary Samples.

作　　者：余玲玲[1] 温怀凯[1] 杨海蔚[1] 邵美娟[1] 徐永安[1] 

机构地区：[1]浙江省温州医学院附属第二医院检验科,325027

出　　处：《医学研究杂志》2006年第10期30-31,共2页Journal of Medical Research

摘　　要：目的探讨茶碱在老年慢性阻塞性肺病(COPD)患者静脉血和唾液中浓度的相关性。方法采用化学发光免疫分析法同时测定静脉滴注氨茶碱注射剂患者,给药前(0h)及开始给药后0．5h、1．5h、5h、8h、12h静脉血和唾液的茶碱浓度,并分析其相关性。结果患者静脉血和唾液茶碱浓度相关性好(r=0．86),经统计学分析,呈显著性相关(p＜0．05)；唾液茶碱浓度达蜂时间迟于静脉血,给药后5h开始唾液茶碱浓度与静脉血茶碱浓度测定结果无显著性差异(P＞0,05)。结论用唾液代替静脉血测定茶碱浓度,减轻了患者的病苦,节约了医疗劳动,有利于临床上广泛开展茶碱药物浓度的监测。Objective To Study the correlation of the theophylline concentrations in venous blood and salivary samples of old patients with chronic obstructive pulmonary diseases （ COPD）. Methods The theophylline concentrations in venous blood and salivary samples collected before intravenous injection （ 0 h ） and after intravenous injection 0.5 h, 1.5 h, 5 h ,8 h, 12 h were determined simuhaneously with chemiluminescence immunoassay（CLIA）. Results The correlation of the theophylline concentrations between venous blood and salivary samples was good （ r = 0.86 ） ; There are no significant difference of the theophylline concentrations between venous blood and salivary samples since after intravenous injection 5h. Conclusions Salivary samples can be used instead of venous blood in clinical monitoring of theophylline concentrations. It can relieve the patient＇s pain and reduce the medical works.

关 键 词：茶碱 唾液 静脉血 

分 类 号：R563.3[医药卫生—呼吸系统]