应变率评价左室肥厚大白兔左室局部舒张功能  

Assessment of Left Ventricular Regional Diastolic Function in Rabbits with Left Ventricular Hypertrophy by Strain Rate

作　　者：毕玉堂 范义[2] 胡卫东[2] 

机构地区：[1]深圳市南澳医院,广东深圳518116 [2]深圳市龙岗中心医院,广东深圳518116

出　　处：《北华大学学报（自然科学版）》2006年第5期433-435,共3页Journal of Beihua University（Natural Science）

摘　　要：目的 探讨应变率评价大白兔左室肥厚模型左室局部舒张功能的可行性．方法40只大白兔分别给予假手术、主动脉缩窄和主动脉缩窄＋血管紧张素受体拮抗剂干预，于4周和8周进行心脏超声检查，测量常用心功能参数，于心尖四腔切面记录二尖瓣口血流频谱，记录心尖四腔切面的定量组织速度成像图像，脱机分析后室间隔基底部舒张早期峰值应变（SRe）和左房收缩期峰值应变（SRa），并计算SRe／SRa．结果左室肥厚组实验8周时，室壁增厚，左室舒张末内径增大，左室心肌重量增加，与假手术组同期和本组4周相比均有显著性差异（P〈0．05）．伊贝沙坦组实验8周时左室心肌重量与左室肥厚组相比有显著性差异（P〈0．05）．左室肥厚组SRe／SRa与假手术组相比有显著性差异（P〈0．05）．伊贝沙坦组Ve／Va小于1的大白兔数量明显少于左室肥厚组．结论应变率曲线能够直观反映大白兔局部心肌舒张功能状况，是评价动物模型左室局部舒张功能的较好方法．Objective To probe the feasibility of the assessment of left ventricular regional diastolic function in rabbits with left ventricular hypertrophy by strain rate. Methods 40 rabbits with LV hypertrophy due to banding of the ascending aorta （LVH） and 10 age-matched sham-operated rabbits were involved in our study, LVH rabbits were randomized to no treatment （n = 14） or treatment with angiotensin receptor antagonist irbesartan（30 mg/kg/day, n = 14）. 4 weeks and 8 weeks after aortic banding, M-mode echocardiograms and transmitral Doppler spectra and QTVI image of 4-chamber view at cardiac apex were recorded. The left ventricular wall thickness and the left ventricular end-diastolic diameter were measured through M-mode echocardiography, LV mass was calculated. The peak strain rates of early diastole （SRe） and artrial contraction（SRa） of the basal septum were measured, and SRe/SRa was calculated. Results At 8 week the left ventficular wall thickness and the left ventricular end-diastolic diameter and LV mass of LVH rabbits were increased more than that of sham-operated rabbits significantly（ P 〈 0.05）. LV mass of irbesartan rabbits were lower than that of LVH rabbits significantly（P 〈 0.05）. The SRe/SRa of LVH rabbits was less than that of sham-operated rabbits significantly（P 〈 0.05）. The quantity of irbesartan rabbits which value of SRe/ SRa less 1 was fewer than that of LVH rabbits. Conclusion Strain rate curve could reflect the regional diastolic function directly. It is a good method to assess animal regional diastolic function.

关 键 词：超声心动图 家免 应变率 左室局部舒张功能 

分 类 号：R54[医药卫生—心血管疾病]