不同剂量重组乙型肝炎疫苗(酵母)阻断乙型肝炎病毒母婴传播的研究  

Research on Perinatal Transmission of Hepatitis B Virus by Using Different Doses Yeast-derived Hepatitis B Vaccine

作　　者：孙莲英[1] 庞志钊[2] 张文英[3] 江永珍[3] 余陶[3] 王俊明[4] 张勇[3] 刘崇柏[3] 

机构地区：[1]海南省疾病预防控制中心,海口570203 [2]石家庄市卫生防疫站,河北石家庄050011 [3]中国疾病预防控制中心病毒病预防控制所,北京100052 [4]河北医科大学,石家庄050017

出　　处：《中国计划免疫》2006年第4期262-263,共2页Chinese Journal of Vaccines and Immunization

基　　金：本课题经费由中国肝炎防治基金会提供

摘　　要：目的了解国产不同剂量重组乙型肝炎(乙肝)疫苗(酵母)阻断乙肝病毒(HBV)母婴传播的效果。方法用5μg/0.5ml和10μg/0.5ml重组乙肝疫苗(酵母)免疫乙肝病毒表面抗原(HBsAg)、乙肝病毒膜抗原(HBeAg)双阳性母亲的新生儿68例,采用0、1、6个月接种程序,用固相放射免疫(SPRIA)法定量检测乙肝病毒表面抗体(抗-HBs)滴度及HBsAg。结果全程免疫后1个月,10μg剂量组新生婴儿HBsAg阳性率为2.86%,保护率为96.43%;5μg剂量组的HBsAg阳性率为3.45%,保护率为95.69%。10μg、5μg剂量组的抗-HBs阳转率分别为97.14%、82.76%,产生的抗-HBs几何平均浓度分别为237.44毫国际单位/毫升(mIU/ml)、150.06mIU/ml。10μg组的抗体阳转率明显高于5μg组。结论重组乙肝疫苗(酵母)母婴阻断效果良好,10μg组的免疫原性高于5μg组。Objective To study the efficacy of different doses yeast-derived Hepatitis B vaccine （YDV） to neonates born to HBsAg,HBeAg carrier mother. Methods 68 neonates born to HBsAg,HBeAg carrier mother were vaccined in two groups （5 /lg dose and 10 /lg dose） by 0,1,6 month schedule. Result Vaccined newborns HBsAg positive rate of 10 μg group is 2.86%, the protective rate is 96.43 % ; HBsAg positive rate of 5μg group is 3.45 %, the protective rate is 95.69 % . The anti-HBs seroconversion rate is 97.14%, 82.76%, the mean geometric concentration （GMC）of anti-HBs is 237.44 mIU/mL and 150.06 mIU/mL after 1 month of full vaccination schedule in 10/~g dose group and 5μg dose group respectively. Conclusion The effective anti-HBs conversion rates in 10μg dose group is significantly higher than 5 μg dose group. These results revealed the high efficacy of YDV.

关 键 词：重组乙型肝炎疫苗(酵母) 免疫效果 

分 类 号：R186[医药卫生—流行病学] R512.62[医药卫生—公共卫生与预防医学]