尖锐湿疣患者治疗前后血清IL-2、IL-6和TNF-α水平检测的临床意义  

Clinical Significance of Measurement of Serum IL-2,IL-6 and TNF-α Levels Before and After Treatment in Patients with Condyloma Acumimatum

作　　者：梁宁[1] 

机构地区：[1]海南省海口市人民医院放免中心,海南海口570208

出　　处：《标记免疫分析与临床》2006年第3期155-156,共2页Labeled Immunoassays and Clinical Medicine

摘　　要：为探讨尖锐湿疣患者治疗前后的血清IL-2、IL-6、TNFα-水平及其临床意义,分别应用RIA法和ELISA法对42例尖锐湿疣患者测定血清IL-2、IL-6和TNFα-水平,并与30名健康人(正常组)作比较。结果表明,尖锐湿疣患者在治疗前血清TNF-α水平显著高于正常组(P<0.01),而IL-2、IL-6则显著低于正常组(P<0.01),经6个月治疗后,与正常组比较仍有显著性差异(P<0.05)。结论:尖锐湿疣患者的免疫功能存在明显缺陷。To study the changes of serum IL-2, IL-6 and TNF-α levels before and after treatment in patients with condyloma acuminatum, the IL-2, IL-6 and TNF-α levels in 42 patients and 30 healthy controls were measured by RIA and ELISA respectively. The results showed that the TNF-α level in patients was extremely higher than that in control group （P〈0.01）. IL-2 and IL-6 levels in patients were extremely lower than those in control group（P%0.01）. After treatment 6 months, the TNF-α level in patients was still higher than that in control group （P% 0.05）; the IL-2 and IL-6 levels in patients were still lower than those in control group （P% 0.05）. It suggested that condyloma acuminatum patients may have some autoimmunedeficincy.

关 键 词：尖锐湿疣 白细胞介素-2 白细胞介素-6 肿瘤坏死因子-α 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]