腰骶部背根神经的脉冲射频对细胞因子的影响  被引量:5

Effect of pulsed radiofrequency treatment of the lumbosacral dorsal root on cytokines

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作  者:谭嵘[1] 徐军美 蒋劲 

机构地区:[1]中南大学湘雅二医院麻醉科,湖南长沙410011 [2]深圳南山医院麻醉科,广东深圳518000

出  处:《中国医学工程》2006年第4期358-359,363,共3页China Medical Engineering

摘  要:目的观察腰骶部背根神经的脉冲射频对细胞因子TNF-、IL-1和IL-6的影响。探讨脉冲射频可能的机制。方法对18例保守治疗无效的神经根性腰腿痛患者,在影像学引导下进行穿刺定位行背根神经脉冲射频治疗,在行背根神经的脉冲射频前24(hT0),术毕后即时(T1),术毕后6(hT2),术毕后24(hT3),术毕后4(hT4),术毕后72(hT5),分别抽取肘静脉血测定TNF-a、IL-1和IL-6浓度并对患者进行活动时视觉模拟尺度评分(VAS)评分。结果与行背根神经的脉冲射频前24h比较,术毕后6(hT2),术毕后24(hT3),术毕后48(hT4),术毕后72(hT5)的TNF-浓度逐渐下降(P<0.05),与T0比较T3、T4、T5IL-1和IL-6的浓度明显降低。与T0比较T1、T2、T3、T4、T(5,VAS)明显改善(P<0.05)。结论腰骶部背根神经脉冲射频通过降低细胞因子TNF-a、IL-1和IL-6的产生,对神经根性疼痛有治疗作用。[ Objective ] To investigate the effect of pulsed radiofrequency treatment of the lumbosacral dorsal root on cytokines and to explore the potential mechanism of the pulsed radiofrequency. [Methods] Eighteen patients with lumbosacral radicular pain treated with pulsed radiofrequency after conservative therapy were retrospectively evaluated. Blood samples were taken 24 h before pulsed radio-frequency, after operation, 6 h after operation, 24 h after operation, 48 h after operation, and 72 h after operation for determination of plasma levels of TNF-, IL-1, IL-6 activity. The ten-point VAS was used. [Result] The plasma levels of TNF- at T2, T3, T4 and T5 were significantly lower after pulsed radiofrequency, compared to T0- The plasma levels of IL-1, IL-6 at T3, T4 and T5 were significantly lower after pulsed radiofrequency, compared to To. [Conclusion] It suggests that the use of pulsed radiofrequency in the treatment of the lumbosacral radicular pain appears to be effective by inhibiting plasma TNF-a, IL-1, IL-6.

关 键 词:背根神经 脉冲射频 视觉模拟尺度评分 细胞因子 

分 类 号:R454.1[医药卫生—治疗学]

 

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