阿魏酸钠缓释小丸的制备及体外释药特性  

Preparation and release characteristics of sodium ferulate sustained-release pellets

作　　者：张立超[1] 全山丛[1] 胡晋红[1] 周德波[1] 吕艳红 

机构地区：[1]第二军医大学附属长海医院药学部,上海200433 [2]烟台警备区门诊部,山东烟台264000

出　　处：《中成药》2006年第10期1414-1416,共3页Chinese Traditional Patent Medicine

基　　金：上海市科学技术委员会中药现代化科研计划项目(03Z19526)

摘　　要：目的:制备阿魏酸钠(SF)缓释小丸,初步评价其体外释药特性及释药机制。方法:离心造粒法制备空白丸芯及载药小丸;以乙基纤维素水分散体Surelease为包衣材料,流化床制备SF缓释小丸;释放度试验考察小丸的体外释药特性及释药机制。结果:包衣小丸表面光滑圆整,不同批次间小丸释药重现性良好;2种小丸配比而成的SF缓释胶囊释药随包衣膜厚的增加而减慢;后处理时间为24 h;小丸的体外释药符合H iguch i方程。结论:SF缓释小丸具有较理想的体外缓释效果。AIM： To prepare the sodium ferulate sustained-release pellets and evaluate its release characteristics and release mechanism in vitro. METHODS： Sugar core beads and drug-containing pellets were prepared by centrifugal granulation, and then coated by Surelease using the fluid-bed. The release characteristics and release mechanism of the pellets were studied by the dissolution method. RESULTS ： The surface of the coated pellets was smooth and glossy and round. The release rate of sodium ferulate met lot-to-lot uniformity. The release rate of the pellet consisted of two kinds of pellets decreased with the increasing of the film thickness. The finishing time was 24 h. The dissolution profiles of sodium ferulate from the pellets showed a good fit of the Higuchi equation.CONCLUSION： The pellets exhibit more ideal sustained-release characteristics in vitro.

关 键 词：缓释小丸 离心造粒 流化床 包衣 阿魏酸钠 

分 类 号：R944.22[医药卫生—药剂学]