北京市MSM人群HIV感染者合并HCV与梅毒感染的状况及相应免疫指标与病毒载量的变化  

Study of HIV infection,co-infection with STDs and HCV and related changes in immunological indicators and viral loads among men who have sex with men in Beijing

作　　者：张晓燕[1] 王晨[2] 李新旭[1] 张晓曦[2] 宋艳辉[1] 李东亮[2] 李深伟[1] 马丽英[1] 师伟[2] 徐建青[1] 杨振凯[2] 阮玉华[1] 洪坤学[1] 邢辉[1] 邵一鸣 

机构地区：[1]中国疾病预防控制中心性病艾滋病预防控制中心,北京100050 [2]北京市朝阳区疾病预防控制中心,北京100021

出　　处：《中国艾滋病性病》2006年第4期294-296,320,共4页Chinese Journal of Aids & STD

基　　金：国家"十五"科技攻关课题资助项目(2004BA719A01)

摘　　要：目的 了解北京市男男性接触者（MSM）的艾滋病病毒（HIV）感染及宿主的免疫状态。方法 2005年7～12月对招募的MSM进行HIV感染检测，采集阳性感染者的外周血，对分离毒株进行鉴定，并对阳性感染者的免疫状态包括CD4^＋、CD8^＋T细胞的数量，以及感染者体内病毒载量进行了分析。结果在招募的526名MSM中，HIV感染的主要流行亚型为欧美B亚型，1例为CRF01-AE重组亚型，后者主要为异性间HIV感染的流行亚型。HIV感染者中合并HCV或者梅毒的感染率分别为17．65％与35．29％，合并感染者的CD4^＋、CD8^＋T淋巴细胞数量明显降低，病毒载量明显升高。结论 MSM人群中HIV感染者合并STD感染，明显降低宿主免疫系统控制病毒复制的能力，同时存在着MSM人群与其他高危人之间通过性途径相互传播HIV的趋势。Objective To elucidate HIV infection and immunity status among men who have sex with men（MSM）in the face of an increasing risk of HIV-1 infection by both hetero-and homo-sexual transmission accounting for 43,6% of overall HIV infection. Method HIV infection was tested among recruited MSM in Beijing and their blood specimens were collected and virus strains were solated and tested. Immunity status including CD4^＋, CD8^＋ T cell counts and viral loads was assayed in these with positive HIV antibodies. Result Of the 526 MSM individnals 17 were confirmed as HIV-1 positive, and the co-infection rates with HCV or syphilis among them were 17.65 % and 35.29 %, respectively. The amounts of both CD4^＋ T cells and CD8^＋ T cells were significantly decreased in HIV positive cases co-infected with HCV or syphilis, and their viral loads were increased by 6-7 folds accordingly.The circulabng HIV-1 strains isolated in this population group were identified as HIV-1 subtype. In contrast to teports of heterosexual transnission of subtype CRF01-A/E HIV-1 and min cnculaling subtype B/C in China,mest of the circnlating virus strains in our study populstion were subtype B,and one was subtype CRF01-A/E.Conclusion Coinfection of HIV with STDs has obviously decreased mmunity against virus replication in MSM population group,and there is a tendency of spreading HIV infections through sex between MSM and other high risk population groups.

关 键 词：男男性接触者 艾滋病病毒 病毒载量 免疫检测 合并感染 

分 类 号：R373[医药卫生—病原生物学]