基于微/纳米加工技术的微型电化学免疫传感器研究  

Micro Electrochemical Immunosensor Based on Micro/Nano Fabrication Technology

作　　者：许媛媛[1] 边超[1] 陈绍凤[1] 夏善红[1] 

机构地区：[1]中国科学院电子学研究所传感技术联合国家重点实验室北方基地,北京100080

出　　处：《传感技术学报》2006年第05B期2149-2152,共4页Chinese Journal of Sensors and Actuators

基　　金：国家自然科学基金资助重点项目(90307014)

摘　　要：生物传感器的研制越来越趋向于微型化、集成化、智能化以及无创伤的方向发展.研制基于微/纳米加工技术的电化学免疫传感器顺应了这一趋势,利用微电子机械系统(MEMS)技术在硅基芯片上制备微型三电极系统和SU-8微型池,并采用自组装单层膜和纳米金修饰微型电极表面用于抗体的固定化,研制出新型的电化学免疫传感器.研究表明,这种微型电化学免疫传感器易于实现批量生产,便于集成,检测过程只需要少量的样品,大大降低有毒试剂的消耗,减少环境污染,同时具有分析成本低,响应时间快,检测下限低和适用于现场快速检测等优点.The research and development of biosensor is marching toward miniaturization, integration, intelligence and non-invasion. Study on the electrochemical immunosensor based on micro/nano fabrication technology is of great significance in practical application. A novel immunosensor has been developed by employing MEMS technology, self-assembled monolayers （SAMs） and gold nanoparticles （nanogold） for the preparation of micro electrode system and the immobilization of antibody. This kind of miniature sensors allows for low-cost production in batch processes and compatibility with CMOS technology, needs only a small amount of sample solution, reduces the consumption of toxic reagents, decreases the environmental pollution, enables relatively rapid, reliable and inexpensive field-analysis.

关 键 词：微/纳米加工技术 微型电化学免疫传感器 微电子机械系统(MEMS) 抗体 

分 类 号：TP212.2[自动化与计算机技术—检测技术与自动化装置]