糖基化代谢终产物与动脉粥样硬化关系的研究进展  

Progress of Relationship between Metabolic End Product of Glycosylation and Atherosclerosis

作　　者：刘杰[1] 韦金儒[1] 

机构地区：[1]广西医科大学第一附属医院心血管内科,南宁530021

出　　处：《医学综述》2006年第20期1275-1277,共3页Medical Recapitulate

摘　　要：糖基化代谢终产物(AGEs),是指蛋白质、脂质或核酸等大分子在没有酶参与的条件下,自发地与葡萄糖或其他还原单糖反应所生成的稳定的共价加成物。AGEs与AGEs受体结合,通过复杂的机制,引起血管内皮细胞的通透性增高和动脉平滑肌细胞增殖。但是由于AGEs在体内存在形式的多样性,如何抑制其病理作用的中间环节成为目前研究的主要方向。AGEs are stable covalence affixtures through the spontaneous reaction between macromolecules including protein,lipid or nucleinic acid and Glucose or other hydrogenize monosaccharide without ensyme. AGEs can combine with receptor of AGEs and cause increased permeability of vascular endothelial cell and proliferation of arterial smooth muscle cell through complicated mechenism. Because of its variety in existing form in our body, how to inhibit its middle process about pathological effect is still a deserving study direction at present.

关 键 词：动脉粥样硬化 糖基化代谢终产物 糖基化代谢终产物受体 丝裂原活化蛋白激酶 

分 类 号：R543.5[医药卫生—心血管疾病]