Dendritic tellurides acting as antioxidants  

作　　者：XU Huaping WANG Yapei WANG Zhiqiang LIU Junqiu Mario Smet Wim Dehaen 

机构地区：[1]Key Lab of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, China [2]Key Lab for Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130023, China [3]Laboratory for Organic Synthesis, University of Leuven, Celestijnenlaan 200E B-3001 Leuven, Belgium

出　　处：《Chinese Science Bulletin》2006年第19期2315-2321,共7页

基　　金：This work was supported by the National Natural Science Foundation of China(Grant Nos.20334010,20474035,20473045,20574040 and 20573042);the Flemish government,the University of Leuyen and the F.W.0.Vlaanderen(Grant No.BIL 02/03).

摘　　要：We have described the synthesis of a series of poly(aryl ether) dendrimers with telluride in the core and oligo(ethylene oxide) chains at the pe- riphery which act as glutathione peroxidase (GPx) mimics. These series of compounds were well characterized by H-NMR, 1 13C-NMR and ESI-MS. Using different ROOH (H2O2, cumene hydroperoxide) for testing the antioxidizing properties of these com- pounds, we have found that from generation 0 to 2, the activity of the dendritic GPx mimics first de- creased and then increased. This can be explained on the basis of a greater steric hindrance, going from generation 0 to 1, and stronger binding interactions going from generation 1 to 2. In other words, there exists a balance between binding interactions and steric hindrance that may optimize the GPx activity.We have described the synthesis of a series of poly（aryl ether） dendrimers with telluride in the core and oligo（ethylene oxide） chains at the periphery which act as glutathione peroxidase （GPx） mimics. These series of compounds were well characterized by ^1H-NMR, ^13C-NMR and ESI-MS. Using different ROOH （H2O2, cumene hydroperoxide） for testing the antioxidizing properties of these compounds, we have found that from generation 0 to 2, the activity of the dendritic GPx mimics first decreased and then increased. This can be explained on the basis of a greater steric hindrance, going from generation 0 to 1, and stronger binding interactions going from generation 1 to 2. In other words, there exists a balance between binding interactions and steric hindrance that may optimize the GPx activity.

关 键 词：抗氧化剂 碲化物 谷胱甘肽过氧化物酶 氧化乙烯 合成 

分 类 号：O627[理学—有机化学]