先兆早产孕妇牙周状况与妊娠结局的关系  

Associations between periodontal status and delivery outcomes in pregnant women with a diagnosis of threatened premature labor

作　　者：李晓军[1] 孔经贾[1] 陈晖[1] 梁峰冰[2] 贺晶[2] 

机构地区：[1]浙江大学医学院附属口腔医院口腔内科,杭州310006 [2]浙江大学医学院附属妇产医院产四科

出　　处：《中华口腔医学杂志》2006年第10期599-601,共3页Chinese Journal of Stomatology

基　　金：浙江省医药卫生重点科技项目计划基金(2002A062)

摘　　要：目的通过比较先兆早产(TPL)孕妇与健康孕妇的牙周状况,对牙周病变程度、血清肿瘤坏死因子α(TNF-α)水平与早产间的关系作初步探讨。方法收集 TPL 孕妇40例(TPL 组),同期做定期产前检查无产兆的健康孕妇40名(对照组)。TPL 组中26例足月产(TPL-TB),14例早产(TPL-PB);对照组均足月产。检查记录菌斑指数(PLI)、探诊深度(PD)、临床附着丧失(CAL)和出血指数(BI),并计算牙周炎位点(PD>3 mm,CAL≥2mm)率。ELISA 法检测血清 TNF-α水平。结果TPL 组的 PLI(0.94±0.05)、牙周炎位点率(2.93%)和血清 TNF-α水平[14.81 ng/L(13.40～15.64 ng/L)]均明显高于对照组的0.59±0.03、1.32%和11.47 ng/L(10.82～12.86 ng/L),P<0.001。TPL-PB 组的 PLI(0.96±0.06)、BI(2.99±0.14)、牙周炎位点率(3.61%)和 TNF-α水平[18.35ng/L(15.47～31.94 ng/L)]显著高于 TPL-TB 组的0.66±0.04、2.76±0.12、2.25%和13.70 ng/L(12.64～14.80ng/L)。分娩孕周和牙周炎位点率、TNF-α水平呈显著负相关(P<0.05)。TNF-α水平与牙周炎位点率呈显著正相关(P<0.05)。结论牙周感染可能是早产的原因之一。Objective To evaluate the association between periodontal conditions and delivery outcomes in pregnant women with a diagnosis of threatened premature labor （TPL）. Methods Eighty systemically healthy pregnant women were enrolled in the study. Forty of these were pregnant women hospitalized with the diagnosis of TPL, and 40 normal pregnant women served. TPL was control clarified as TPL-PB （14 women ） and TPL-TB （26 women） based on the delivery outcomes. No infants were delivered as PB in the control with non-TPL. Periodontal examinations included assessments of plaque index （ PLI）, clinical attachment loss （ CAL）, probing depth （ PD ）, bleeding index （BI） and the percentage of periodontitis sites（ PD 〉 3 mm, CAL ≥ 2mm ）. The serum level of TNF-α was determined using commercially available enzyme-linked immunoassays （ELISA）. Results The mean PLI （0. 94 ± 0. 05 ）, percentage of periodontitis sites（2. 93% ） and TNF-α levels[ 14. 81ng/L （ 13.40±15.64 ng/L） 1 were significantly higher in the TPL group than in the non-TPL group [ 0. 59 ± 0. 03, 1.32% and 11.47ng/L （ 10. 82-12. 86） ng/L 1 （ P 〈 0. 001 ）. The mean PLI（ 0.96 ± 0.06）, BI （2.99 ± 0. 14） , percentage of periodontitis sites （3.61%） and TNF- levels[ 18.35 ng/L（15. 47-31. 94） ng/L] were significantly higher in the TPL-PB group than in the TPL-TB group[0. 66 ± 0.04, 2. 76 ± 0. 12, 2. 25% and 13.70 ng/L（ 12. 64-14. 80 ng/L） ]. Significant negative correlations were observed between the gestational age at delivery and percentage of periodontitis sites as well as serum TNF-α levels（P 〈 0.05）. And significant positive correlations were observed between percentage of periodontitis site and serum TNF-α levels （P 〈0. 05 ） . Conclusions Periodontal inflammation mizht be involved in the Dathozenesis of Dreterm birth.

关 键 词：牙周炎 妊娠结局 先兆早产 

分 类 号：R714.2[医药卫生—妇产科学] R781.4[医药卫生—临床医学]