Nm23/NDPK的多种生物活性及其机制研究进展  

Current progress in pleiotropy and mechanism of Nm23/NDPK

作　　者：熊盛[1] 邢少璟[2] 钱垂文[1] 王一飞[2] 

机构地区：[1]暨南大学药学院制药工程教研室 [2]暨南大学生物医药研究开发基地,广东广州510632

出　　处：《中国病理生理杂志》2006年第10期2066-2070,共5页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助(No.30371661No.30400071);广东省自然科学基金团队项目资助(No.2004E039213)

摘　　要：Human Nm23 family consists of eight gene products that have been implicated in cellular differentiation,development and apoptosis,as well as oncogenesis and tumor metastasis.The protein products of Nm23 are nucleoside diphosphate kinases(NDPKs),the key metabolic enzymes that catalyze the synthesis of nucleoside triphosphates(NTP) by transfer of the terminal phosphate between NDP and NTP.Recent investigations are focused on the extraordinary pleiotropy and its mechanism of Nm23/NDPK.In this article,we review the recent progress in studies of the mechanism of Nm23/NDPK as metastasis suppressors,and other bioactivities of NDPK out of phosphate transfer enzyme,as well as the character of NDPK’s quaternary structure and the relation between its structure and function.In addition to these,the potential applications of NDPK as an enhancer of antiviral drugs or Nm23 as a drug target were also described.Findings herein summarized provide new and intriguing suggestions for a more extensive understanding of the biological functions of the star molecule,Nm23/NDPK.Human Nm23 family consists of eight gene products that have been implicated in cellular differentiation, development and apoptosis, as well as oncogenesis and tumor metastasis. The protein products of Nm23 are nucleoside diphosphate kinases （NDPKs） , the key metabolic enzymes that catalyze the synthesis of nucleoside triphosphates （NTP） by transfer of the terminal phosphate between NDP and NTP. Recent investigations are focused on the extraordinary pleiotropy and its mechanism of Nm23/NDPK. In this article, we review the recent progress in studies of the mechanism of m23/NDPK as metastasis suppressors, and other bioactivities of NDPK out of phosphate transfer enzyme, as well as the character of NDPK＇s quaternary structure and the relation between its structure and function. In addition to these, the potential applications of NDPK as an enhancer of antiviral drugs or Nm23 as a drug target were also described. Findings herein summarized provide new and intriguing suggestions for a more extensive understanding of the biological functions of the star molecule, Nm23/NDPK.

关 键 词：基因 Nm23 核苷二磷酸激酶 

分 类 号：Q71[生物学—分子生物学]