MR扩散加权成像诊断膝关节骨关节病髌骨软骨病变的价值  

MR diffusion weighted imaging study on patella cartilage applied to osteoarthritis of knee joint

作　　者：刘斯润[1] 朱天缘[1] 陈汉方[1] 吴荷嘉[1] 

机构地区：[1]暨南大学附属第一医院影像中心,广州510630

出　　处：《中华放射学杂志》2006年第10期1098-1101,共4页Chinese Journal of Radiology

摘　　要：目的探讨 MR 扩散加权成像(DWI)在膝关节软骨早期病变诊断中的临床应用价值。方法 18例正常健康志愿者36个膝关节、10例骨关节炎(OA)患者18个膝关节行常规序列及 DWI序列扫描。测量髌软骨各个感兴趣区的表观扩散系数(ADC)值,比较各组间的差异。结果正常健康志愿者组36个髌软骨 ADC 均值(ADCav)为(7.8±2.3)×10^(-4)mm^2/s,髌软骨上、中、下部的 ADC值分别为(7.9±2.3)×10^(-4)mm^2/s、(7.7±2.7)×10^(-4)mm^2/s、(7.9±2.5)×10^(-4)mm^2/s,之间差异无统计学意义(F=0.050,P=0.951)。OA 患者髌软骨 ADCav 为(10.5±4.1)×10^(-4)mm^2/s,髌软骨上、中、下部的 ADC 值分别为(10.8±4.1)×10^(-4)mm^2/s、(10.4±4.4)×10^(-4)mm^2/s、(10.5±4.2)×10^(-4)mm^2/s,之间差异无统计学意义(F=0.940,P=0.910)。但 OA 组的 ADC 值明显高于正常组,两组间差异有统计学意义(t=-2.577,P=0.017),其中以髌软骨内侧份 ADC 值改变最为显著。结论MR DWI 能发现常规 MR 软骨信号尚未改变的更早期软骨病变。Objective To evaluate the clinical significance of quantitative measurement ADC value of patella cartilage on MR diffusion weighted imaging （DWI）. Methods Thirty-six knees of healthy volunteers and 18 of osteoarthritis（OA） were imaged with routine MR sequences and DWI. The ADC of each part of patella were measured and compared with each other. Results In healthy volunteers, the ADCav of patella cartilage was （7. 8 ± 2. 3 ） × 10^-4mm^2/s and the ADCav among superior-middle-inferior portions was not significantly different （ F = 0. 050, P = 0. 951 ）. The ADCav of superior-middle-inferior portions was （7. 9 ± 2. 3） × 10 ^-4mm^2/s, （7. 7 ± 2. 7 ）× 10^ -4 mm^2/s, （7.9 ± 2. 5 ） × 10 ^-4 mm^2/s, respectively. In OA patients, the ADCav of patella cartilage was （ 10. 5 ±4. 1 ） × 10^-4mm^2/s and the ADCav among superiormiddle-inferior portions was not significantly different also （F = 0. 940, P = 0. 910）. The ADCav of superiormiddle-inferior portions was（ 10. 8 ± 4. 1 ） × 10^ -4 mm^2/s, （ 10.4 ± 4. 4 ） × 10 ^-4 mm^2/s, （ 10. 5 ± 4. 2 ） × 10^-4mm^2/s,respectively. The ADCav of the healthy volunteers was lower than that of the OA group（t = - 2. 577, P = 0. 017 ） and the medial part showed the most different. Conclusion DWI is a useful method in detecting early cartilage injury which can not be showed on routine sequences.

关 键 词：软骨 关节 骨关节病 膝关节 磁共振成像 扩散 

分 类 号：R445.2[医药卫生—影像医学与核医学] R684[医药卫生—诊断学]