乙型肝炎卡介苗联合疫苗与单价乙型肝炎疫苗免疫效果的比较  

Comparison of immune effects between hepatitis B-BCG combined vaccine and hepatitis B vaccine

作　　者：金立杰[1] 赵小琳[2] 罗璇[2] 蔡岩[2] 董雪林[2] 李惟[1] 

机构地区：[1]吉林大学生命科学院,长春130021 [2]长春生物制品研究所疫苗一室,长春130062

出　　处：《中国免疫学杂志》2006年第10期952-955,共4页Chinese Journal of Immunology

基　　金：吉林省科技发展计划项目(编号20050402-1)资助

摘　　要：目的:比较乙型肝炎卡介苗联合疫苗与单价乙型肝炎疫苗的免疫效果。方法:实验动物采用豚鼠,按0、1、2月三针免疫程序接种,并于每针免疫后1个月采血,ELISA方法检测血清抗体滴度。实验分三部分进行。实验一:三种不同规格的联合疫苗与单价乙型肝炎疫苗的比较;实验二:同一规格连续三批联合疫苗与单价乙型肝炎疫苗的比较;实验三:联合疫苗与两种单价疫苗同时免疫的比较。结果:在三个实验中,联合疫苗组第一针血清抗体滴度均低于对照组,但无统计学差异;联合疫苗组第二、三针血清抗体滴度均高于对照组,也无统计学差异,实验组各组之间无明显差异。结论:联合疫苗组三针免疫程序的HBsAg的效力与单价乙型肝炎疫苗组相似。Objective：To compare immune effects of hepatitis B-BCG combined vaccine and hepatitis B vaccine. Methods：The vaccines were administered to the guinea pig at 0, 1,2 months. The tests were divided into three parts. The immune effects were compared in three kinds of the combined vaccine and hepatitis B vaccine（ Part One）, in three lots of the combined vaccine and hepatitis B vaccine（Part Two）, in the group of combined vaccine and the group of hepatitis B vaccine and BCG（ Part Three）. After 1 month of each vaccine dose, serum specimens were measured for anti-HBs by ELISA. Results：The several studies have documented the serum anti-HBs concentritious in the group of combined vaccine in first dose were lower than those of the group of control, and the data showed no significantly difference. However, anti-HBs levels of the combined vaccine group in second vaccine dose and third vaccine dose were higher than those of the control group, and this difference was no longer statistically significant in group of combined vaccine and control, and among groups of combined vaccine. Conclusion：The immune efficacy of HBsAg in group of combined vaccine is similar to the group of hepatitis B vaccine in three doses immunization schedules.

关 键 词：乙型肝炎疫苗 卡介苗 联合疫苗 免疫效力 

分 类 号：R512[医药卫生—内科学]