动态观察^(131)I治疗对Graves病患者血清细胞因子水平的影响  

Dynamic study on the influence of the serum cytokine levels in patients with Graves′ disease before and After Treated With ~1(31)I

作　　者：谢克俭[1] 张琦[2] 夏玉祥[2] 管瑜[1] 

机构地区：[1]温州医学院检验医学院放射免疫中心,温州325035 [2]温州医学院核医学室,温州325027

出　　处：《中国免疫学杂志》2006年第10期956-958,共3页Chinese Journal of Immunology

基　　金：浙江省教育厅科研基金资助项目(20041050);温州市"新世纪551人才工程"基金资助项目(2004-551-2)

摘　　要：目的:探讨131I治疗对Graves病(GD)患者血清细胞因子水平的影响。方法:用放射免疫分析法检测52例GD患者131I治疗前及治疗后30、90和180天血清IL-1、IL-2、IL-6、IL-8、TNF-α水平,并与血清甲状腺激素进行相关性分析,30例年龄与性别相匹配的健康者作为正常对照。结果:GD患者血清IL-1、IL-6、IL-8、TNF-α水平显著高于对照组(P<0·01),IL-2显著低于对照组(P<0·01);经131I治疗,甲状腺功能恢复正常后,IL-1、IL-8水平明显降低,IL-2明显升高,与对照组比较差异无显著性(P>0·05);IL-6、TNF-α明显低于治疗前(P<0·01),但仍高于对照组(P<0·05)。血清IL-1、IL-6与FT3呈正相关(P<0·05),IL-2与FT3呈负相关(P<0·05)。结论:131I治疗能有效抑制GD患者自身免疫,其治疗前后血清细胞因子的变化可反映GD的免疫动态,可能与发病机制、治疗效果和预后有关。Objective：To study the influence of the serum cytokine levels of patients with Graves＇ disease（GD） before and After Treated With ^131 I. Methods： Using the method of radioimmunoassay, the serum levels of interleukin-1 （ IL-1 ）, interleukin-2 （ IL-2）, interleukin-6（IL-6）, interleukin-8（IL-8） and tumor necrosis factor（TNF-α） of GD 52 patients were measured before and after ^131 I, 30 age-and sex-matched healthy subjects served as controls, and the results were compared with that of the control group. Results ：The levels of IL-1, IL-6, IL-8, TNF-α of GD patients were significantly higher than that of the control group（ P 〈0. 01 ）, the levels of IL-2 of GD patients were significantly lower than that of the control group（ P 〈 0. 01 ）. The serum IL-1, IL-8, IL-6, TNF-α levels of GD patients of after treated with ^131I were significantly lower than those before treatment（ P 〈 0. 01 ）, whereas serum IL-2 level was higher （ P 〈 0.01 ）. The serum levels of IL-1, IL-6 positively correlated with FT3 （ P 〈 0.05 ）. There was a negative correlation between IL-2 and FI3 （P 〈 0. 05 ）. Conclusion：Successful ^131 I therapy would effectively suppress the auto-immune status in GD patients; Cytokines play certain roles in the progressing of GD, and the serum cytokines levels might reflect the immune activity and be implicated in immunopathology Graves＇disease and prognosis.

关 键 词：GRAVES病 白细胞介素1 白细胞介素2 白细胞介素6 白细胞介素8 肿瘤坏死因子-α ^131I治疗 

分 类 号：R581[医药卫生—内分泌]