不同基质利福平栓剂的制备及质量考察  

Preparation and quality check of different bases of rifampicin suppositories

作　　者：杨倩[1] 丑晓华[1] 刘浩楠[1] 矫建[1] 岳彬[2] 田舸[3] 田燕[3] 

机构地区：[1]大连医科大学 [2]大连市友谊医院麻醉科,辽宁大连116001 [3]大连医科大学药学院药剂学教研室,辽宁大连116027

出　　处：《大连医科大学学报》2006年第5期398-399,401,共3页Journal of Dalian Medical University

摘　　要：[目的]制备不同基质的利福平栓剂并进行质量考察.[方法]采用紫外-可见分光光度法测定利福平的溶出度,并检查不同比例栓剂的融变时限.[结果]利福平检测浓度在10.0～60.0 μg/mL范围内线性关系良好,平均回收率为100.33%（RSD=1.23%）.筛选出最佳基质为甘油明胶,与利福平的最佳配比为5∶1,其融变时限为（25.6±0.94）min,符合中国药典要求.[结论]该制剂制备方法简单,成本低,质量可控.[Objective] To prepare different bases of rifampicin （RFP） suppositories and to check its quality. [Methods] The content of RFP was determined by UV assay and the melt time of different proportion suppositories was examined. [Results] The line arrange for RFP concentration was 10.0～60.0 μg/mL, the average recovery was 100.33 % （RSD = 1.23 %）. The best base was glycerin-glutin, its best proportion to RFP was 5：1, and its melt time was （25.6±0.94）min, according to the request of Chinese pharmacopoea. [Conclusion] The prepared method of RFP suppositories is simple, the cost is low, and its quality is controlled.

关 键 词：利福平 栓剂 制备 质量 

分 类 号：TQ463.2[化学工程—制药化工]