活血承气汤对小肠缺血再灌注家兔小肠及肺组织NF-κB活性的影响  

Effects of Huoxue Chengqi(活血承气)Herbs on the Activation of NF-κB in Rabbit Intestinal and Lung Tissue during Intestinal Ischemia-Reperfusion

作　　者：杨涛[1] 崔乃强[2] 郭世铎[2] 李东华[2] 王宇歆[2] 

机构地区：[1]天津市第一中心医院移植外科,天津300192 [2]天津市中西医结合急腹症研究所

出　　处：《中国中西医结合外科杂志》2006年第5期482-484,共3页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

基　　金：为2002年天津市科学技术委员会优势领域医学项目(023111511-1);天津市中西医结合急腹症研究所博士研究生课题部分内容

摘　　要：目的:观察和探讨应用活血承气汤(HXCQ)对小肠缺血再灌注家兔小肠及肺组织NF-κB活性的影响。方法:建立小肠缺血再灌注家兔模型,采用电泳迁移率改变分析方法(electrophoretic mobility shiftassay,EMSA),分析活血承气汤灌胃后不同时段小肠缺血再灌注家兔小肠以及肺组织NF-κB活性的变化。结果:应用活血承气汤后小肠缺血再灌注家兔小肠和肺组织NF-κB活性显著降低。结论:应用活血承气中药可显著减轻小肠缺血再灌注引起的小肠及肺组织损伤。Objective To observe the activation of NF-κB in rabbit intestinal and lung tissue during intestinal ischemia-reperfusion and effects when Huoxue Chengqi（活血承气） Herbs（Hxcq） being used Methods The activation of NF-κB in intestinal and lung tissue of rabbit intestinal I/R models was detected by electrophoretic mobility shift assay （EMSA）. Results The level of NF - κB in intestine and lung tissue apparently decreased by using Huoxue Chengqi herbs. Conclusion The level of NF-κB in intestine and lung tissue can be reduced by Huoxue Chengqi in the process of intestinal ischemia-reperfusion. So Huoxue Chengqi can be used to reduce the degree of inflammation when ischemiareperfusion occur and reduce the lung injury at the same time.

关 键 词：NF—κB 缺血再灌注 电泳迁移率改变分析 活血承气汤 

分 类 号：R285.5[医药卫生—中药学]