参附注射液对实验性急性坏死性胰腺炎肠道细菌移位的影响  

Action of ShenFu(参附)Injection on Bacterial Translocation from Intestine in Acute Necrotizing Pancreatitis

作　　者：张红[1] 毕旭东[2] 葛春林[3] 于继刚[1] 董晓松[1] 

机构地区：[1]辽宁省锦州市中心医院普外一科,锦州121000 [2]锦州医学院附属第一医院胆胰外科 [3]中国医科大学附属第一医院胆胰外科

出　　处：《中国中西医结合外科杂志》2006年第5期485-488,共4页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

摘　　要：目的:研究参附注射液对实验性急性坏死性胰腺炎(ANP)时肠道细菌移位的影响。方法:ANP大鼠制模方法采用胰腺被膜下注射牛磺胆酸钠。假手术组、对照组经皮下注射生理盐水,实验组同法给予等量参附注射液。取标本(下腔静脉血、腹水、肠系膜淋巴结及大肠内容物)进行细菌培养,计数菌落数及鉴定细菌种类。结果:标本中生长的细菌与大肠内容物培养细菌种类相同,实验组标本的菌落数少于对照组(P<0,01)。结论:实验性ANP大鼠合并感染的细菌来源于肠道,参附注射液可以减少肠道细菌移位。Objective To explore the action of ShenFu（参附） Injection on bacterial translocation from intestine in acute necrotizing pancreatitis（ANP） Methods The ANP models in rats were induced by injecting taurocholate into pancreas through fine needle. The sham operation group and the control group were administered 3 ml normal saline after onset of ANP. The experiment group was administered the same amount of ShenFu Injection. Laparotomy was performed and samples of ascites, venous blood and mesenteric lymph node（MLN） were obtained for bacterial culture. The bacteria -colonies of all the samples were calculated after culture. Results The bacterial species in each sample were the same as that of colon contents. The bacteria-colony number of each sample in the experimental group was lower than that in control（ P 〈 0.01 ）. Conclusion The bacteria in infection of experimental ANP rats were from the colon. ShenFu injection can decrease the bacteria translocation in acute necrotizing pancreatitis.

关 键 词：参附注射液 急性坏死性胰腺炎 细菌移位 大鼠 

分 类 号：R285.5[医药卫生—中药学] R657.51[医药卫生—中医学]