维生素E对尾部悬吊大鼠雄性生殖损伤的防护作用  

Protective Effects of Vitamin E on Injury to Male Reproductive Function in Tail-suspended Rats

作　　者：周党侠[1] 邱曙东[1] 王志勇[1] 张洁[1] 

机构地区：[1]西安交通大学医学院生殖医学中心

出　　处：《航天医学与医学工程》2006年第5期337-339,共3页Space Medicine & Medical Engineering

基　　金：陕西省科技攻关重点项目(2005K15-G2);陕西省中医管理局中医药科研课题(2005024);西安交通大学自然科学基金资助(540326)

摘　　要：目的研究维生素E(VE)对尾部悬吊大鼠雄性生殖损伤的防护作用。方法选用性成熟期健康SD雄性大鼠30只,随机分为对照组、尾吊组、VE+尾吊组3组。14d后观察各组大鼠的睾丸重量、形态,精子数量和质量以及血清激素含量。结果与对照组相比,尾吊组大鼠睾丸重量、精子数量和质量以及血清睾酮含量均显著下降(P<0.05)。VE可以显著改善这些指标(P<0.05)。另外,尾吊组大鼠睾丸生精小管萎缩,间质水肿。生精上皮层数减少,细胞排列松散,生精小管腔内的精子数明显减少。VE+尾吊组大鼠睾丸形态结构部分恢复正常,生精小管腔内的精子数量增多。结论VE对尾部悬吊造成的大鼠雄性生殖损伤有防护作用。Objective To study the protective effects of vitamin E（VE） on injury to male reproductive function in tail-suspended rats. Method Thirty adult male Spraque-Dawley（SD） rats were randomly divided into three groups：control, TS （tail-suspension） and VE ＋ TS groups. TS and VE ＋ TS groups were tail-suspended for 14 d,and VE was given orally to VE ＋ TS group during tail-suspension. After the treatment, weight and morphology of testes, quality and amount of sperm, as well as serum hormones were observed. Result As compared with the control group, weight of testes, quantity and quality of sperm, as well as serum testosterone decreased significantly in TS group （P 〈0.05）. VE treatment was helpful in restoring these parameters （P 〈0.05）. In addition, hematoxylin and eosin （HE） stained specimens showed atrophy of seminiferous tubules, decrease of spermatogenic cells, disintegrated and shed seminiferous epithelial cells, and azoospermic lumina in rats of TS group. VE treatment significantly improved the testicular structures. Conclusion VE has protective effects on the injury to male reproductive function induced by tail-suspension in rats.

关 键 词：失重模拟 尾吊 生殖 维生素E 

分 类 号：R852.22[医药卫生—航空、航天与航海医学]