股骨颈骨折后髋关节软骨退变的生物力学研究  

Effects on Biomechanical Properties of Hip Articular Cartilage Degeneration Following the Femoral Neck Fracture in Rabbits

作　　者：宋文锴[1] 裴福兴[1] 向明 刘波 

机构地区：[1]四川大学华西医院骨科,成都610041 [2]成都体育医院骨科,成都610041

出　　处：《生物医学工程学杂志》2006年第5期1024-1027,共4页Journal of Biomedical Engineering

摘　　要：在动物模型上研究股骨颈骨折后髋关节软骨退变在发生、发展、转归过程中软骨厚度和生物力学特性改变及其与伤后时间的关系。用新西兰白兔60只作股骨颈基底截骨制作骨折动物模型,于术后2、4、6、8、12、16周采用压凹法测定关节软骨厚度和生物力学特性。兔股骨颈骨折后关节软骨持续增厚,6周达高峰,随后软骨迅速磨损、变薄;骨折后4周起软骨退变失代偿,弹性和机械强度进行性大幅度下降,退变至骨关节炎。股骨颈骨折后保守治疗形成局部低应力环境,关节软骨缺乏动态载荷,基质胶原网络迅速降解所引起的生物力学特性降低是导致并维持软骨退变不断前进的动力。Osteotomies were performed through postolateral approach under the base of femoral neck on 60 New Zealand white rabbits. The changes of the thickness and biomechanical properties of acetabular cartilage following the cartilage degeneration and the relationship to the postoperative time 2, 4, 6, 8, 12, 16 weeks later were measured respectively. The cartilage specimens were harvested and measured by the automated creep indentation apparatus to obtain the thickness and biomechanical properties. The cartilage became thicker within 6 weeks after operation, cartilage degeneration developed critically from the surface with the lost of the biomechanical properties. The degeneration progressed till the eartilage became thinner and thinner and the to be torn out into pieces at last. The matrix of articular cartilage degraded markedly for the absence of normal stress load following the femoral neck fracture, led to the decline of the biomechanical properties and kept the degeneration progress to osteoarthritis.

关 键 词：股骨颈骨折 关节软骨 生物力学 退行性变 

分 类 号：R683.42[医药卫生—骨科学]