血管紧张素I转换酶基因插入/缺失多态性与人体速度耐力的关联研究  

An Association Study between the Insertion/deletion Polymorphism of Angiotensin I Converting Enzyme Gene and Human Speed Endurance

作　　者：刘涛[1] 孙学川[1] 

机构地区：[1]解放军体育学院军事体能训练研究中心,广州510502

出　　处：《生物医学工程学杂志》2006年第5期1045-1047,共3页Journal of Biomedical Engineering

摘　　要：探讨人体血管紧张素I转换酶基因插入/缺失多态性与速度耐力之间的关联性。聚合酶链反应扩增技术检测受试者基因型;测定受试者800 m跑成绩和血乳酸浓度,并对成绩进行逐步聚类分析,将受试者分为高速度耐力组和低速度耐力组。结果发现:高速度耐力组和低速度耐力组组间血管紧张素I转换酶基因型分布及等位基因分布皆无显著性差异(P>0.05);血乳酸浓度无论是安静状态、800 m跑后,还是800 m跑后与安静状态的差值,各基因型组间皆无显著性差异(P>0.05)。人体血管紧张素I转换酶基因插入/缺失多态性与速度耐力无关。This study was conducted to research the association between the insertion/deletion （I/D） polymorphism of Angiotensin Ⅰ converting enzyme （ACE） gene and human speed endurance. Fourty subjects of Han nationality, healthy, with similar sports history were included. The I/D polymorphism of ACE gene was detected by polymerase chain reaction （PCR）. The score of 800m run and the concentrations of the whole blood lactic acid were mensurated. Cluster analysis of the grade was made according to the result of cluster analysis. The subjects were divided into two groups ：high speed endurance group and low speed endurance group. We found that both the distributions of the ACE genotypes and the distributions of the ACE alleles there were no significant difference between high speed endurance group and low speed endurance group（P〉0.05）;Whether at rest state, or after 800m run or the difference value between rest and after 800m run,the concentrations of the whole blood lactic acid did not exist significant difference among three kinds of genotypes groups （P〉0. 05）. There was on association with I/D polymorphism of ACE gene and human speed endurance.

关 键 词：血管紧张素Ⅰ转换酶 基因多态性 速度耐力 

分 类 号：R87[医药卫生—运动医学]