医用磷酸钙骨水泥的制备及性能的实验研究  

Preparation and Properties of Medical Calcium Phosphate Cement

作　　者：郑治[1] 向其军[2] 刘咏[2] 苏哲安[2] 王剑龙[1] 肖飞[1] 

机构地区：[1]中南大学湘雅三医院,长沙410013 [2]中南大学粉末冶金国家重点实验室,长沙410083

出　　处：《生物医学工程学杂志》2006年第5期1048-1051,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金主任基金资助项目(30370412);湖南省自然科学基金资助项目(03JJY3027)

摘　　要：探索了磷酸四钙（Ca4（PO4）2O，TTCP）的制备，并合成了磷酸钙骨水泥（CPC），对CPC固化时间、引起浸泡液pH值的变化、抗压强度、产物物相组成及微观结构进行了研究。结果表明：在真空条件下、1500℃下煅烧6h可制得TTCP，并含有少量CaO。CPC初凝时间为4min、终凝时间为15min，浸泡1d和7d后的抗压强度分别为20MPa和35MPa，浸泡液的pH值在6．4～8．9之间变化，这些性能均符合临床用CPC的性能要求。CPC水化产物为片状或针状羟基磷灰石（Ca5（PO4）3OH，HA），相互交错呈连续分布的网状结构，这种结构有利于材料强度的提高。实验研制的CPC材料可用于骨缺损的修复治疗。The preparation of tetracalcium phosphate （Ca4（PO4）2O, TTCP）was studied. Then calcium phosphate cement （CPC）was prepared. The setting time, pH value, compressive strength, X-ray diffraction （XRD） and scanning electron microscope （SEM） analysis of CPC were studied. The results show that TTCP containing small amount of CaO can be successfully attained heated at 1 500℃ for 6 h in vacuum condition. The initial setting time and final setting time of CPC is 4 min and 15 min, respectively. Its compressive strength is 20 MPa after 1-day immersion and 35 MPa after 7-day immersion. The pH value of the solution changes between 6.4 and 8.9. These properties can satisfy the clinical requirements of CPC. The final product of CPC is flake-like or needle-like hydroxyapatite （Cas（PO4）3OH, HA）. The continuous network structure of HA appears in the microstructure, this leads to increase the strength of the material. This CPC can be used as bone substitute material.

关 键 词：磷酸钙骨水泥 磷酸四钙 制备 固化时间 抗压强度 

分 类 号：R318.08[医药卫生—生物医学工程]