OPG、OPGL在骨肉瘤中的表达及其意义  

Expressions of OPG and OPGL in Osteosarcoma and Their Significance

作　　者：周鹏[1] 邵增务[1] 徐润冰[1] 

机构地区：[1]华中科技大学同济医学院协和医院骨科,武汉430022

出　　处：《肿瘤防治研究》2006年第10期748-749,共2页Cancer Research on Prevention and Treatment

摘　　要：目的探讨OPG及OPGL在骨肉瘤中的表达及意义。方法采用免疫组化方法研究骨肉瘤、骨软骨瘤中OPG、OPGL的表达并分析其差异性。结果骨肉瘤与骨软骨瘤OPG的表达有显著性差异,骨肉瘤与骨软骨瘤OPGL的表达无显著性差异。结论骨肉瘤中存在OPG高表达,可能与骨肉瘤的成骨性有关。Objective To investigate the expression of OPG and OPGL in osteosarcoma and its signifi cance. Methods The expression of OPG and OPGL in human osteosarcoma tissue,osteochondroma was detected by immunohistochemistry. Results The expressing rate of OPG was significant different between osteosarcoma and osteochondroma. The expressing rate of OPG was not significant different between osteosarcoma and osteochondroma. Conclusion There was overexpression of OPG in human osteosarcoma. The expression of OPG may have a close correlation with the ossifying of osteosarcoma.

关 键 词：OPG OPGL 骨肉瘤 骨软骨瘤 

分 类 号：R392.11[医药卫生—免疫学]