新生儿缺氧缺血性脑病早期综合干预的效果观察  

Observing the effect of early general intervention on neonatal hypoxic-ischemic encephalopathy

作　　者：赵芳[1] 张学红[1] 吴玉华[1] 刘芳[1] 

机构地区：[1]宁夏医学院附属医院新生儿科,宁夏银州750004

出　　处：《中国妇幼保健》2006年第20期2815-2817,共3页Maternal and Child Health Care of China

摘　　要：目的：评价中、重度新生儿缺氧缺血性脑病（HIE）患儿早期干预的效果。方法：对64例干预组予以早期家庭干预为主，辅以医学干预、营养干预及康复治疗，59例对照组出院后常规育儿。生后6、12、18个月时均进行Gesell智测。结果：6、12、18个月时干预组平均发育商（DQ）比对照组高14．5分、16．1分、17．4分，t值分别为5．758、6．077、7．987，P〈0．01，差异有显著性，随着干预时间延长，发育商越高。NBNA评分30-34分的患儿，经综合干预18个月DQ均可达正常，而≤29分者，CT及临床呈重度改变，经18个月干预未达正常，差异有显著性。结论：早期综合干预能有效促进HIE患儿的智能发育，7-14d NBNA评分30-34分者，干预效果良好；7-14d NBNA评分≤29分，CT和临床呈重度改变的患儿，干预效果较差。以家庭为基础的干预是最有效的途径。Objective： To evaluate the effect of early intervention on moderate and severe neonatal hypoxic - ischemic encephalopathy （ HIE ） . Methods： The intervention group （64 cases） accepted the primarily early intervention and auxiliary treatment including medi- cal intervention, nutritional intervention and convalescent treatment. The control group （59 cases） accepted routine treatment. The development quotient （DQ） of two groups were evaluated by the Gesell development scales on the 6th, 12th, 18th month respectively. Results： The intervention group had higher DQ than control group （P 〈0. 01 ）. The DQ was increased while the intervenient time was prolonged. The DQ of those infants whose neonatal behavior neurological assessment （NBNA） were higher than 30 points during the 7th to 14th day was close to normal level through 18 - month＇s early intervention, but the DQ of those infants whose NBNA were lower than 29 points during the 7th to 14th day couldn＇t reach the normal level. Conclusion： The early general intervention can effectively promote the intelligent development of HIE infants. The intervenient effect is associated with NBNA during the 7th to 14th day.

关 键 词：新生儿缺氧缺血性脑病 早期综合干预 

分 类 号：R722[医药卫生—儿科]