检索规则说明:AND代表“并且”;OR代表“或者”;NOT代表“不包含”;(注意必须大写,运算符两边需空一格)
检 索 范 例 :范例一: (K=图书馆学 OR K=情报学) AND A=范并思 范例二:J=计算机应用与软件 AND (U=C++ OR U=Basic) NOT M=Visual
作 者:常彩红[1] 牛德亮[2] 张展[1] 贾莉婷[1]
机构地区:[1]郑州大学第三附属医院检验科,河南郑州450052 [2]河南中医学院第一附属医院检验科
出 处:《中国妇幼保健》2006年第20期2849-2851,共3页Maternal and Child Health Care of China
摘 要:目的:探讨IGF-Ⅱ在子痫前期发病机制中的作用。方法:用免疫组织化学方法检测正常晚孕组和轻度、重度子痫前期患者胎盘组织中IGF-Ⅱ的表达,同时用ELISA方法检测3组研究对象胎儿脐血中IGF-Ⅱ的含量。结果:IGF-Ⅱ在脐血中的含量,重度子痫前期组显著高于轻度子痫前期组(P<0.001),轻度子痫前期组显著高于正常晚孕组(P<0.01);IGF-Ⅱ在胎盘组织中的表达,重度子痫前期组显著低于轻度子痫前期组(P<0.01),轻度子痫前期组显著低于正常晚孕组(P<0.01)。结论:子痫前期时脐血IGF-Ⅱ含量升高可能是子痫前期病理变化的结果,而胎盘组织中IGF-Ⅱ表达减少可能是引发子痫前期的重要因素之一。Objective: To explore the effect of insulin - like growth factor - Ⅱ (IGF - Ⅱ ) on the pathogenesis of preeclampsia. Methods: The umbilical serum IGF - Ⅱ levels in twenty one normal pregnancy and ninety - tree preeclamptic patients was detected by ELISA ; The expression of IGF - Ⅱ in placental tissue was measured by immunohistochemistry SP. Results: The content of IGF - Ⅱ in umbilical serum was significantly higher in severe preeclampsia group than that of mild preeclampsia group ( P 〈0. 001 ) and that of mild preeclampsia group were obviously higher than that of normal pregnancy group ( P 〈 0. 01 ) ; The expression of IGF - Ⅱ in severe pregnancy placentas were obviouslyly lower than that of mild preeclampsia group ( P 〈 0. 01 ) and both were significantly lower than that of normal group ( P 〈0. 01 ) . Conclusion: The [GF - Ⅱ level in placentas could be a key factor involved in the pathogenesis of preeclampsia; and the content of IGF - II in umbilical serum could be the result of pathogenesis of preeclampsia.
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在链接到云南高校图书馆文献保障联盟下载...
云南高校图书馆联盟文献共享服务平台 版权所有©
您的IP:216.73.216.117