养血清脑颗粒对收缩压影响的实验研究  

Eexperimental study on the systolic blood pressure of Yang-xue-qing-nao granule

作　　者：康立源[1] 高秀梅[1] 郭志军[1] 李晶[1] 樊官伟[1] 张伯礼[1] 

机构地区：[1]天津中医学院中医药研究中心,天津300193

出　　处：《中国临床药理学杂志》2006年第5期353-355,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的 研究养血清脑颗粒（降血压药）对自发性高血压大鼠（SHR）的降压作用.方法 用SHR模型和大鼠尾动脉脉搏测压法,观察养血清脑颗粒（31.5,15.8,7.8 g·kg^-1,每天灌胃给药）对SHR收缩血压的影响.结果 单次灌服养血清脑颗粒约1h,开始显示降压作用,2～3 h达最高降压效果;连续给药2周后,高剂量组与模型组比较即有显著性差异（P＜0.05）;给药8周后,试验组与模型组比较均有显著性差异（P＜0.05或P＜0.01）.结论 养血清脑颗粒有降低SHR收缩压的作用.Objective To investigate the antihypertensive effect of Yang -xue -qing- nao granule （YXQN） on spontaneous hypertensive rat （spontaneous hypertensive rat, SHR ）. Methods The effect of YXQN （31.5,15.8,7.8 g · kg^-1 ,ig,q 12 h） on the systolic blood pressure of SHR by the tail cuff method were observed. Results At the time after a single ig administration of YXQN, the blood pressure was decreased at 2 -3 h. While at the time after a multiple ig adiministration, the systolic blood pressure were decreased. Compared with model group, trial group had significant difference. Conclusion YXQN can reduce the systolic blood pressure of SHR.

关 键 词：自发性高血压大鼠 高血压 养血清脑颗粒 

分 类 号：R972.4[医药卫生—药品] R965.1[医药卫生—药学]