过敏性紫癜β_2微球蛋白的改变  

Beta2-microglobulin in Children with Henoch-Schonlein Purpura

作　　者：孙晓春[1] 陈明钰[1] 

机构地区：[1]唐都医院小儿科

出　　处：《第四军医大学学报》1990年第5期336-337,共2页Journal of the Fourth Military Medical University

摘　　要：作者用放射免疫技术检测过敏性紫癜患儿血清及尿β_2-微球蛋白(Beta2-microglobulin,β_2-MG)。结果发现,过敏性紫癜发病初期血清β_2-MG(N=30,2.68±0.61mg/L)高于恢复期(N=20,201±0.37mg/L)和对照组(N=30,211±0.48mg/L),而恢复期与对照组无显著差别。过敏性紫癜发病初期尿β_2-MG(N=30,0.505±0.623mg/L)高于恢复期(N=20,0.051±0.036mg/L)和对照组(N=30,0.058±0.056mg/L),而恢复期与对照组无差异。推测过敏性紫癜可伴有肾小管—间质的毛细血管或小静脉炎的损害,而血清及尿β_2-MG可作为过敏性紫癜性肾炎有效而敏感的指标之一。By radioimmunoassay the serum and urinal beta2-microglobulin in children with Henoch-Sehonlein Purpura (HSP) were detected. Serun beta2-microglobulin was significantly higher in the early phase (N=30, 2.68±0.61mg/L) than in the convalescent phase(N=20,2.01±0.37 mg/L) and the controls (N=30, 2.11±0.48 mg/L) In the convalescent phase it did not differ from that of the controls. Urinal beta2-microglobulin was higher in the early phase (0.505±0.623mg/L) than in the convalescent phase (0.051±0.036 mg/L)and of the controls(0.058±0.056 mg/L). In the convalescent phase it did not differ from that of the controls. It is important to look for a better criterion to find subclinical nephritis,because 29% of our patients are nephritis. Beta2-microglobulin not only can give information concerning renal function, but also concerning abnormal immune function.

关 键 词：紫癜 Β2微球蛋白 血清 尿 

分 类 号：R554.6[医药卫生—血液循环系统疾病]