医学生减量接种乙肝疫苗近期的效果  

An Observation on Immunogenic Effects of Low Dose Hepatitis B Vaccine in Medical Students

作　　者：李远贵[1] 郭群恩[2] 徐德忠[1] 杨望山[2] 陈民新 周华[1] 肖乐义[1] 陈友绩[1] 

机构地区：[1]第四军医大学流行病学教研室 [2]第四军医大学卫生处

出　　处：《第四军医大学学报》1990年第6期427-429,共3页Journal of the Fourth Military Medical University

摘　　要：作者对HBV血清学标记均阴性的193名医学生分别肌肉注射25,5,10μg乙肝疫苗,按0,1,6月方案接种,并随访观察1年.注射3次乙肝疫苗后,3个剂量组的抗-HBs应答率均在90％以上,在首次注射后1,4,7,12月时,无论是抗-HBs应答率或抗-HBs S/N均值在3个剂量组之间均无显著差别。本观察近期结果提示,在医学生中接种2.5μg剂量疫苗代替常规的10μg疫苗,可以节省资金,扩大接种人数,缓和乙肝疫苗供应紧张状况。One hundred and ninety three medical students who were confirmed to be negative for all HBV sero - markers were randomly injected with 2.5, 5 , 10 μg hepatitis B vaccine respectively. Vaccine was injected intramuscularly at 0, 1st, 6th and 12th month. One month after the third injection, anti HBs scro covcrsion rates in three dose groups were over 91%. At 1st, 4th, 7th and 12 th month after the first injection, there were no significant differences either in anti - HBs sero - conversion rales or in the mean values of anti HBs S/N among the three dose groups. Protective rate of vaccine was 92 % in one year.

关 键 词：乙型肝炎 病毒性肝炎 疫苗 抗体 

分 类 号：R512.620.3[医药卫生—内科学]