椒苯酮胺在比格犬体内的药代动力学研究  

Pharmacokinetics Study on Peperphentonamine in Beagle Dogs

作　　者：牟英[1] 孟志云[2] 窦桂芳[2] 

机构地区：[1]苏州大学医学院药理教研室苏州中药研究所,江苏苏州215007 [2]军事医学科学院野战输血研究所,北京100085

出　　处：《中国血液流变学杂志》2006年第3期338-340,共3页Chinese Journal of Hemorheology

摘　　要：目的研究椒苯酮胺(peperphentonamine,PPTA)在比格犬体内的药代动力学过程。方法比格犬iv PPTA 2.63,5和10mg.kg-1,用反相HPLC-UV法测定在不同时间血液中的药物浓度。结果比格犬iv PPTA其体内过程符合二室模型,三个剂量的血浆清除半衰期t1/2分别为0.76±0.10、1.26±0.46、1.32±0.35min,各剂量组间无显著性差异(P>0.05);药时曲线下面积AUC分别为4905±1421、10253±3616、24256±5471 ng.min.mL-1(比例为1:2.1:4.9),与给药剂量成正比例增加,具有良好的线性关系(r=0.9988)。结论PPTA在2.63￣10mg.kg-1范围内给比格犬给药,其药时曲线符合二室模型,A U C增加与剂量增加成比例,显示出线性动力学特征。Aim To determine the pharmacokinetics features of peperphentonamine（PPTA） in beagle dogs.Methods Following a single iv administration with different doses of PPTA to beagle dogs（2.63,5 and 10mg·kg^-1）,the blood samples were collected at different time after treatment and the concentration of PPTA in plasma were determined by HPLC-UV method.Results The pharmacokinetic parameters of PPTA after single iv administration of PPTA 2,4 and 8 mg·kg^-1 in beagle dogs were follows：AUC were 4905 ±1421, 10253 ± 3616, 24256± 5471 ng·min·mL^-1, t1/2 were 0.76 ±0.10, 1.26±0.46, 1.32 ±0.35 min,respectively.Conclusion It was shown that the plasma concentration-time data was fit to a double compartment pharmacokinetic model in beagle dogs after iv administration and the elimination of PPTA was found to be in according with linear kinetics characteristics.

关 键 词：椒苯酮胺 比格犬 药代动力学 HPLC测定 

分 类 号：R969.1[医药卫生—药理学]