水中“一锅”合成7,7-二甲基-4-(3-氯苯基)-5-氧代-3,4,5,6,7,8-六氢香豆素的洁净方法  

Clean one-pot synthesis of 4-(3-chlorophenyl)-7,7-dimethyl-5-oxo-3,4,5,6,7,8-hexahydrocoumarin in aqueous medium

作　　者：靳通收[1] 赵瑞巧[1] 王爱卿[1] 杜超[1] 

机构地区：[1]河北大学化学与环境科学学院,河北保定071002

出　　处：《化学试剂》2006年第10期621-622,共2页Chemical Reagents

基　　金：国家自然科学基金资助项目(29872011);教育部高等学校骨干教师资助项目;河北省自然科学基金资助项目(203107)。

摘　　要：研究了四丁基溴化铵(TBAB)催化下的水介质中,3-氯苯甲醛、丙二酸亚异丙酯和5,5-二甲基-1,3-环己二酮三组分缩合,一步合成系列7,7-二甲基-4-(3-氯苯基)-5-氧代-3,4,5,6,7,8-六氢香豆素。产物的结构经IR和1HNMR进行了表征确证。该方法具有反应条件温和、操作简便、环境友好的优点。The 4- （ 3-chlorophenyl ）-7,7-dimethyl-5-oxo-3,4, 5, 6, 7, 8-hexahydrocoumarin ＇was synthesized from 3-chlorobenzaldehyde, 5, 5-dimethyl-1, 3-cyclohexanedione and isopropylidene malonate catalyzed by tetrabutylammonium bromide in aqueous medium. The structures of the product was characterized by IR and 1HNMR. This method provided several advantages such as mild reaction conditions, simple work-up procedure and environment friendly. In addition, water was chosen as a green solvent.

关 键 词：3-氯苯甲醛 丙二酸亚异丙酯 5 5-二甲基-1 3-环己二酮 水介质 合成 

分 类 号：O626.3[理学—有机化学]