D-、L-和DL-青霉胺的太赫兹时域光谱  

Terahertz Time-Domain Spectroscopy of D-,L-,and DL-Penicillamines

作　　者：吉特[1] 赵红卫[1] 张增艳[1] 葛敏[1] 王文锋[1] 余笑寒[1] 徐洪杰[1] 

机构地区：[1]中国科学院上海应用物理研究所,上海201800

出　　处：《物理化学学报》2006年第9期1159-1162,共4页Acta Physico-Chimica Sinica

基　　金：国家自然科学基金(10574134);中国科学院知识创新工程资助项目

摘　　要：利用太赫兹时域光谱技术(THz-TDS)对D-、L-和DL-青霉胺的研究发现,三种样品在0.2THz到1.8THz波段的吸收光谱存在显著差异,实验结果表明,THz吸收光谱能够鉴别青霉胺对映异构体,这一特点将可以用于青霉胺药物的检测.本文利用纯D-、L-青霉胺的THz吸收光谱,对D-、L-青霉胺混合样品的THz吸收光谱进行拟合,证明可以用THz光谱定量分析混合样品中D-、L-青霉胺的相对含量.这项研究为手性药物分子检测和分析提供了新的实验方法,也对深入了解手性药物与生物靶分子之间相互作用提供了启示.Far-infrared absorption spectra of D-, L-, and DL- penicillamines have been measured by terahertz timedomain spectroscopy （THz-TDS） in the frequency range from 0.2 THz to 1.8 THz. The experimental results show large difference among absorption spectra of enantiomers （D- and L- peniciUamines） and their racemic compound （DL- penicillamine）, which probably originated from the difference of crystal structure and vibration modes of crystal lattice. The study indicates that THz-TDS can be used for discrimination of D-, L-, and DL- peniciUamines. The absorption spectra of their mixtures have been fitted by the absorption spectra of D- and L- penicillamines, and we have demonstrated the feasibility of this method to determine quantitatively the mixture ratios of penicillamine enantiomers. These will not only give a new experimental method to distinguish chiral medicine, but also provide a suggestion for further comprehending the interaction of chiral medicine and target biomolecule.

关 键 词：太赫兹时域光谱 D-、L-、DL-青霉胺 对映异构体 定量分析 

分 类 号：R91[医药卫生—药学]