复制蛋白A功能研究进展  

Replication protein A:current progresses

作　　者：刁汇玲[1] 朱心强[1] 杨军[1] 

机构地区：[1]浙江大学医学院毒理学教研室,浙江杭州310031

出　　处：《中国药理学与毒理学杂志》2006年第5期433-436,共4页Chinese Journal of Pharmacology and Toxicology

基　　金：国家高技术研究发展计划(2004AA649120);国家自然科学基金(30300277);国家自然科学基金(30471956)资助项目~~

摘　　要：复制蛋白A(RPA)是目前国内外研究细胞DNA损伤应激反应的热点之一。RPA是真核细胞中主要的单链结合蛋白,包含70-,34-和14-ku 3个亚单位。RPA在DNA复制和修复过程中起着重要的作用。复制开始与延长阶段中,RPA具有解链、结合单链模板并维持DNA连续复制的功能;DNA损伤时,RPA与许多具有染色体结构维持、保护、修复功能的蛋白质簇集在DNA损伤位点,共同完成对DNA损伤的检测并进行修复。Recently, replication protein A （RPA） has become one of the main areas in the study of cellular responses to DNA damage. RPA is the predominant eukaryotic single-stranded DNA binding protein composed of 70, 34, and 14 ku subunits. RPA plays central roles in the processes of DNA replication and repair. During initiation and elongation phases of chromosomal DNA replication, RPA can unwind DNA double-strand, bind DNA single-strand, and maintain DNA replication continuously. During DNA damage, RPA interacts with many proteins that are involved in DNA structural maintenance, protection, and repair,and co-localizes to the sites of DNA damage to detect and repair the damage. This review briefly summarizes the current progresses in the study of RPA function.

关 键 词：复制蛋白A DNA损伤 

分 类 号：R341[医药卫生—基础医学] Q754[生物学—分子生物学]