胎儿股骨次级骨化中心的MRI和组织学检测  

MRI and histology examination of fetal femur secondary ossification center

作　　者：陈建国[1] 张英泽[1] 潘进社[1] 马晓晖[2] 孟钊[3] 李智勇[1] 

机构地区：[1]河北医科大学第三医院创伤急救中心,石家庄050031 [2]河北医科大学第三医院MRI室,石家庄050051 [3]河北省儿童医院,石家庄050031

出　　处：《解剖学杂志》2006年第5期621-623,共3页Chinese Journal of Anatomy

基　　金：河北省自然科学基金(C2004000609)

摘　　要：目的:探讨用MRI检测骨化中心出现的时间、位置、形态等,和组织学进行对比性研究。方法:用FLASH2D梯度回波加脂肪抑制序列检测了胎龄6-8个月女性股骨远近端。同时与相应组织学H-E染色标本比较。结果:MRI检测结果:胎龄7个月+的81％股骨远端出现骨化中心征象,骨化中心始于偏心位。8个月+的股骨远端均出现骨化中心征象。胎龄7个月+、8个月+的股骨近端和6个月+股骨远近端均未出现骨化中心征象。H-E切片观测结果:证实了MRI检测阳性区有早期骨化中心征象。结论:MRI能检测出早期表达区,早于X线中所见,骨化中心见于骨组织尚未完全形成之前。Objective： To explore the emerging time,situs and morphous of ossification center with MRI examination,and compare the results with histology. Methods：The distal and proximal femoral parts of 6 8 months fetuses were scanned by FLASH2D ＋ FS gradient echo associated with fat-supression sequence, and compare with histological examination with HE stain. Results： In MRI group, 81% in 7 months group displayed ossification center. The ossification center was located between the middle and upper of 1/3 longitudinal axis of distal femoral epiphysis, and between the middle and posterior of 1/3 sagittal axis of cartilaginous epiphysis. The ossification center displayed in all samples of 8 months group , but not did at distal femur in 7 months group and 8 months group , and distal, proximal femur in 6 months group. Histological examination has confirmed there are ossification center in the MRI positive portion. Conclusion： The ossification center displayed in MRI Lis earlier than that in X-ray. The ossification center appears before bone tissues form.

关 键 词：胎儿 股骨 次级骨化中心 磁共振成像 组织学 

分 类 号：R321[医药卫生—人体解剖和组织胚胎学]