超声造影剂肝渡越时间对肝良恶性病变诊断的临床意义  

The clinical value of hepatic transit time for differentiating benign and malignant focal lesion in liver

作　　者：周翔[1] 张艳容[1] 项飞翔[1] 林铤[1] 严天慰[1] 冷松[1] 谢明星[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院超声影像科,武汉430022

出　　处：《中华超声影像学杂志》2006年第10期761-763,共3页Chinese Journal of Ultrasonography

摘　　要：目的 探讨超声造影剂肝渡越时间（hepatic transit time，HTT）对肝良恶性病灶鉴别诊断的临床意义。方法 良性病灶组包括22例局灶性脂肪肝和50例血管瘤；恶性病灶组包括26例原发性肝癌，16例转移性肝癌。经肘静脉弹丸注射超声造影剂声诺维，计算超声造影剂HTT。结果 良性病灶HTT值波动范围大，其HTT范围6～17s，平均（10．5±2．3）s。恶性病灶HTT均不大于10S．HTT范围3～10s，平均（6．0±1．9）s。以HTT〈10s作为恶性的诊断标准，其敏感性为95．0％，特异性为50．0％，阳性预测值为52.6％，阴性预测值为94．7％。结论 超声造影剂HTT在肝良恶性病变中的价值主要在于对恶性病灶的排除诊断，不适合进行病灶恶性的确切诊断。Objective To ascertain whether a new ultrasound technique, namely hepatic transit time （HTT） ,could differentiate benign and malignant lesion of liver. Methods One hundred and fourteen subjects were scanned using CPS technique, including 16 patients with matastatic liver lesion,26 patients with primary hepatic carcinorma,and 72 control patients with benign liver lesion （50 haemangioma, 22 local fatty liver）. A bolus injection of 1 ml SonoVue was given into an antecubital vein and HTT was calculated. Results HTT range 6 - 7 s [mean （10.5 ± 2.3）s] were found in patients with benign liver lesions,3 - 10 s [mean （6.0 ± 1.9）s] in patients with malignant liver lesions. Comparison of the two groups showed HTT≤10 s in malignant liver lesion patients and 〉10 s apart in benign liver lesion. When HTT〈10 s was taken as point for malignant diagnosis, the diagnostic test was presented sensitivity of 95.2 %, specificity of 50.0 %, and positive predictive value of 52.6 %, negative predictive value of 94.7%. Conclusions HTT is valuable for excluding malignant liver tumor,but not for differentiating maligant liver lesion from benign one.

关 键 词：超声检查 造影剂 肝疾病 

分 类 号：R445.1[医药卫生—影像医学与核医学]