核糖体失活蛋白抗HIV-1作用的研究进展  

Progress in Anti-HIV-1 Actions of Ribosome Inactivating Proteins

作　　者：王建华[1] 欧阳东云[1] 王媛媛[1] 郑永唐[1] 

机构地区：[1]中国科学院昆明动物研究所动物模型与人类疾病机理重点实验室分子免疫药理学实验室

出　　处：《Zoological Research》2006年第5期541-548,共8页动物学研究（英文）

基　　金：国家自然科学基金(39970851);国家"十五"科技攻关计划(2004BA719A14);中国科学院知识创新工程(KSCX2-SW-216;KSCX1-SW-11);云南省自然科学基金(96C095M;1999C0087M;2002C0066M);云南省科技攻关计划(2004NG12)资助课题

摘　　要：核糖体失活蛋白(RIPs)抗HIV-1活性研究已有十几年的历史。RIPs类化合物代表了抗HIV/AIDS天然产物或先导化合物发展的一个重要方向。本文从介绍RIPs的酶活性及其抗HIV-1活性入手,对RIPs抗HIV-1的可能机制,从与RIPs酶活性的关系、诱导HIV-1感染细胞的凋亡及相应的信号转导、诱发活性氧的产生,以及对HIV-1整合酶的抑制作用等几个方面做了较详尽的阐述,并对RIPs的结构修饰和抗HIV-1构效关系进行了综述。对RIPs类化合物在抗病毒领域进行深入而系统地研究,能拓宽其在抗HIV/AIDS临床上的进一步应用。The anti-HIV-1 research history of ribosome inactivating proteins （RIPs） can be traced back to McGrath＇s work in 1989. They are important representatives, which guide further research, of natural anti-HIV products or leading compounds. The enzymatic activities and anti-HIV-1 actions of RIPs were introduced initially in this paper, followed by a detailed discussion about the potential anti-HIV-1 mechanisms. The discussion mainly focuses on the relationships with anti-HIV-1 enzymatic activities, induction of apoptosis of HIV-1 infected cells and responding cell signaling, the production of reactive oxygen species, the HIV-1 integrase inhibition effect. The anti-HIV-1 structure-functional relationship of RIPs and the structural modifications were also covered. Systemic and intensive studies of RIPs＇ antiviral actions will increase their possibility as clinical anti-HIV/AIDS agents.

关 键 词：核糖体失活蛋白 天花粉蛋白 RNA—N糖苷酶 抗病毒机制 HIV-1 

分 类 号：R392[医药卫生—免疫学]