疱疹病毒编码的miRNAs的研究进展  

Advances in Herpesviruses-encoded MicroRNAs

作　　者：戚鹏[1] 韩金祥[1] 鲁艳芹[1] 

机构地区：[1]山东省医学科学院生物技术研究中心山东省病毒学重点实验室,卫生部生物技术药物重点实验室,济南250062

出　　处：《中国生物工程杂志》2006年第10期71-76,共6页China Biotechnology

摘　　要：MicroRNAs(miRNAs)是一类长约22个核苷酸的RNA,在数量、序列、结构、表达和功能上具有多样性。目前,通过生物信息学手段和分子克隆方法,已发现了3518种miRNAs,在控制细胞的生长发育、分化、凋亡等过程中发挥着十分重要的作用。最近研究发现某些病毒基因组也能够编码miRNAs,其中大部分为疱疹病毒,这些miRNAs在调控病毒自身表达以及病毒与宿主相互作用方面可能起到重要的作用。找出病毒可能编码的miRNAs,探索其对病毒感染、复制、表达的作用,有助于病毒分子生物学的研究,也会为研发防治病毒的新方法和新途径提供新的思路。MicroRNAs （miRNAs） are small sequence, structure, abudance, and expression profile. （approximately 22 nt） RNAs that exhibit a diversity in Bioinformatic approaches and direct cloning methods have identified 3518 miRNAs from various species. MiRNAs play a pivotal role in the regulation of genes involved in diverse processes such as development, differentiation, and cellular growth control. Recently, many viral-encoded miRNAs have been discovered, most from the herpesviruses viral family. Virus-encoded miRNAs seem to evolve rapidly and regulate both the viral life cycle and the interaction between viruses and their hosts. The detailed study on the virus-encoded microRNAs and the role they play in the progress of viral infection, replication and expression will be beneficial to understand viral molecular biology, and also provide new strategies for the prevention and treatment of virus.

关 键 词：MIRNAS 疱疹病毒 基因调控 生物信息学 CDNA克隆 

分 类 号：Q52[生物学—生物化学]