2型糖尿病并发肾病患者血清Ⅳ-C和TGF-β_1测定及临床意义  

Clinical Significance of Determination of Serum Collagen TypeⅣ (Ⅳ-C) and Transforming Growth Factor Beta_1 (TGF-β_1) Levels in Patients with Diabetic Nephropathy

作　　者：谢红芳[1] 彭亮[2] 

机构地区：[1]浙江省杭州市第一人民医院内分泌科,310006 [2]浙江省杭州市第一人民医院核医学科,310006

出　　处：《放射免疫学杂志》2006年第5期370-371,共2页Journal of Radioimmanology

摘　　要：目的:探讨2型糖尿病肾病(DN)患者血清Ⅳ型胶原(Ⅳ-C)和转化生长因子-β1(TGF-β1)的变化及临床意义。方法:对105例2型糖尿病(DM2)患者(其中并发DN 45例,未并发DN 60例)和30例正常对照组用放射免疫分析检测Ⅳ-C和用酶免法检测TGF-β1的水平。结果:DN组血清Ⅳ-C、TGF-β1含量明显高于对照组,差异显著(P<0.01),且对照组、未并发DN(NDN)组、DN组血清Ⅳ-C、TGF-β1浓度呈递增趋势,NDN组与对照组相比无统计学意义(P>0.05)。结论:血清Ⅳ-C、TGF-β1含量随着DN的发生以及严重程度逐渐增高,可作为早期诊断DN较敏感的指标,对于监测早期DN的发生和病情发展程度有重要意义。Objective To investigate the clinical significance of determination of serum collagen typeⅣ （Ⅳ - C） and transforming growth factor beta1 （TGF - β1） levels in patients with diabetic nephropathy. Methods Serum Ⅳ - C levels （with RIA） and TGF - β1 levels （with ELISA） were determined in 30 controls and 105 patients with type Ⅱ diabetis mellitus （45 with diabetic nephropathy and 60 without nephropathy）. Results The serum levels of Ⅳ - C and TGF - β1 in diabetic patients with nephropathy were significantly higher than those in controls （P 〈 0.01）. Serum levels in diabetic patients without nephropathy were higher than those in controls, but not significantly （P 〉 0.05）. Conclusion Serum Ⅳ - C and TGF - β1 levels increased gradually as the diabetic nephropathy got more severe, they could be used as sensitive markers for early diagnosis of development of diabetic nephropathy.

关 键 词：糖尿病肾病 Ⅳ型胶原 转化生长因子-Β1 

分 类 号：R587.2[医药卫生—内分泌]