氧化修饰低密度脂蛋白在子痫前期中的测定及意义  被引量:4

Level of oxidant low-density lipoproteins in preeclapsia and significance

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作  者:孟涛[1] 魏军[1] 刘彤[1] 尚涛[1] 潘莉莉[2] 

机构地区:[1]中国医科大学盛京医院妇产科,110003 [2]中国医科大学盛京医院检验科,110003

出  处:《中国优生与遗传杂志》2006年第10期21-21,105,共2页Chinese Journal of Birth Health & Heredity

摘  要:目的测定氧化修饰低密度脂蛋白(oxLDL)在子痫前期中的变化,探讨其意义。方法采用酶联免疫吸附法(ELISA)测定子痫前期重度组、子痫前期轻度组及对照组血清oxLDL水平。结果(1)3组孕妇血清oxLDL比较,见子痫前期重度组升高(49.35±4.22)μg/d l,与对照组(31.71±3.51)μg/d l比较有显著差异(P<0.01);子痫前期轻度组(39.12±2.37)μg/d l升高,与对照组比较有显著差异(P<0.05);子痫前期重度组与轻度组比较无显著差异(P>0.05)。(2)子痫前期重度组血清oxLDL与收缩压、舒张压呈正相关(r=0.51,P<0.01;r=0.47,P<0.05)。结论研究提示oxLDL可能是子痫前期发病的重要因素。Objective: To study the change and clinical significance of oxidant low- density lipoproteins (oxLDL) level in preeclampsia. Methods: Blood serum oxLDL were measured with ELISA. Results: 1. The oxLDL level (49. 35 ±4.22) μg/dl was significantly higher in severe preeclampsia compared with control group (31.71 ±3.51 ) μg/dl ( P 〈0.01 ) ; the oxLDL level (39. 12 ±2. 37 ) μg/dl was significantly higher in light prceclampsia compared with control group ( P 〈 0. 05 ), but had no difference between two groups ( P 〉0. 05). 2. There was a positive correlation between serum oxLDI, and blood pressure ( r =0, 51 ; P 〈0. 01 ; r =0. 47, P 〈 0. 05). Conclusion: oxLDL might be important factors for preeclampsia's occurrence,

关 键 词:子痫前期 氧化低密度脂蛋白(oxLDL) 

分 类 号:R714.245[医药卫生—妇产科学]

 

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