复方岗梅合剂的制备及质量控制  

Preparation and Quality Control of Compound Roughhaired Holly Mixture

作　　者：吴喜英[1] 赖宝龙[1] 李瑞明[1] 邝翠仪[1] 吴爱琴[1] 

机构地区：[1]中山大学附属第一医院药学部,广州市510080

出　　处：《中国药房》2006年第20期1555-1557,共3页China Pharmacy

摘　　要：目的:制备复方岗梅合剂并建立其质量控制方法。方法:以广东土牛膝、岗梅根、甘草制备复方岗梅合剂;采用薄层色谱法对其中的岗梅根、甘草进行定性鉴别;用高效液相色谱法测定其中甘草酸的含量。结果:制得的合剂为棕黑色溶液;薄层色谱对岗梅根、甘草特征斑点定性鉴别清晰,供试品色谱中,在与对照药材色谱相应的位置上显相同的荧光斑点;甘草酸进样量在3.6μg～21.6μg范围内与峰面积积分值线性关系良好,平均回收率为99.95%(RSD=1.62%)。结论:本制剂制备工艺简单,质量控制方法简便、准确、重现性好。OBJECTIVE： To prepare Compound Roughhaired Holly Mixture and establish its quality control standards. METHODS： Qualititive identification of the principal agents like Roughhaired Holly root and glycyrrihizic were performed by TLC ; The content of glycyrrihizic acid was determined by HPLC. RESULTS： The preparation was brownish- black.The spots were clear and centralized, The linear range was 3.6/Lg-21.6μg; the average recovery was 99.95% （RSD = 1.62%） . CONCLUSIONS： The preparing technique of Compound Roughhaired Holly Mixture was simple; the quality control method was stable, accurate and feasible.

关 键 词：复方岗梅合剂 制备 质量控制 高效液相色谱法 

分 类 号：R927.11[医药卫生—药学]