参附注射液联合肉桂防治奥沙利铂神经毒性疗效观察  

Shenfu Injection in Combination with Rougui in the Treatment of Oxaliplatin-induced Neurotoxicity

作　　者：张汀荣[1] 许晨[1] 沈伟生[1] 张瑶[1] 吕叶[1] 

机构地区：[1]东南大学医学院附属江阴医院肿瘤科,江阴市214400

出　　处：《中国药房》2006年第20期1570-1571,共2页China Pharmacy

摘　　要：目的:观察参附注射液联合肉桂防治奥沙利铂神经毒性的疗效。方法:73例恶性肿瘤患者随机分为对照组与治疗组,对照组仅用含奥沙利铂的化疗方案;治疗组在对照组化疗基础上,在化疗前均采用参附注射液40ml～60ml静脉滴注7d～10d+肉桂3g水煎代茶饮。结果:治疗组与对照组的神经毒性总发生率分别为13.5%、55.6%,有显著性差异(P<0.001)。结论:参附注射液联合肉桂能降低奥沙利铂神经毒性发生率。OBJECTIVE： To observe the therapeutic effect of Shenfu Injection in combination of rougui for oxaliplatininduced neurotoxicity.METHODS： A total of 73 cases with malignant tumor were randomly divided into control group and treatment group：the control group was treated with chemotherapy alone,in which oxaliplatin was included;the treatment group was treated intravenously with Shenfu Injection 40-60ml for 7-10d plus orally with 3g Rougui decoction prior to chemotherapy.RESULTS： Incidences of neurotoxicity for the treatment group and the control group were 13.5% and 55.6%, respectively .Significant differences were noted between 2 groups（P （0.001）. CONCLUSION ： Shenfu Injection in combination with Rougui can lower the incidence of neurotoxicity induced by oxaliplatin.

关 键 词：参附注射液 肉桂 奥沙利铂 神经毒性 

分 类 号：R979.1[医药卫生—药品]