不同剂量阿托伐他汀对急性心肌梗死患者胰岛素抵抗的影响  

Influence of the Various Dose of Atorvastatin on Insulin Resistance in Patients with Acute Myocardial Infarction

作　　者：江中喜[1] 李昭骥[1] 陆东风[1] 

机构地区：[1]广州医学院第二附属医院心内科,广州510260

出　　处：《现代食品与药品杂志》2006年第5期20-22,共3页JOurnal of Modern Food and Pharmaceuticals

摘　　要：目的研究不同剂量阿托伐他汀对急性心肌梗死(AM I)患者胰岛素抵抗的影响。方法急性心肌梗死患者60例采用随机的原则分为3组,一组为A组(阿托伐他汀10 mg qd,n=20),一组为B组(阿托伐他汀20 mg qd,n=20),另外一组为C组(阿托伐他汀40 mg qd,n=20),治疗前和治疗8周后分别测血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、空腹血糖(FBG)以及空腹胰岛素(FINS),并计算出胰岛素敏感性指数(ISI)。结果所有急性心肌梗死患者治疗8周后与治疗前比较,胰岛素敏感性指数均有改善(P<0.05),且C组>B组>A组(P<0.05)。结论阿托伐他汀可改善急性心肌梗死患者胰岛素抵抗,改善程度与剂量呈依赖性。Objective To study the influence of various dose of Atorvastatin on insulin resistance（IR） in patients with acute myocardial infarction（AMI）. Methods The levels of fasting serum lipids （TC,TG, LDL-C,HDL-C）, fasting blood glucose （FBG） and fasting blood insulin （FINS） were determined in 60 cases of AMI . Then, 60 cases of AMI were divided into three groups by using a randomized method, A group（ Atorvastatin 10 mg · d^ -1 n = 20）, B group（ Atorvastatin 20 mg · d ^-1, n = 20） and C group （ Atorvastatin 40 mg· d^-1 , n =20）. After a treatment of 8 weeks for all groups, the above indices were determined again. Results After The treat- ment, the insulin sensitivity index （ISI） was significantly increased in all groups（ P 〈0.05 ）, especially in C group after 8 weeks＇treatment of varous doses of Atorvastatin. Conclusion Atorvastatin can dose-dependently improve the IR of patients with AMI.

关 键 词：阿托伐他汀 心肌梗死 胰岛素抵抗 

分 类 号：R969.2[医药卫生—药理学]